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Adenine base editing can be used to correct a genetic variant in preclinical models of hypertrophic cardiomyopathy, and this approach could be applied to other monogenic cardiac diseases.
Researchers have engineered a wearable device that adheres to the skin and uses ultrasound imaging and a deep learning model to produce a dynamic, real-time assessment of cardiac function.
A legally mandated preparticipation screening programme for all young people in Italy engaging in competitive sports has resulted in a very low rate of sports-related cardiac arrest and sudden cardiac death.
The STRONG-HF and COACH trials have shown a reduction in morbidity and mortality in patients with acute decompensated heart failure, for whom therapeutical options are currently limited, using two different approaches that have in common the aim of more effective treatment optimization through a better transition phase from in-hospital to outpatient care.
Health-care delivery is evolving, with an increased availability of consumer and medical technology-enabled diagnostic devices powered by artificial intelligence. Physicians need to evolve by deprioritizing old skills in favour of new skills in statistics and medical decision-making psychology. Technology moves fast; physicians will need to pivot and adapt quickly.
In this Review, Bäckhed and colleagues summarize the evidence for gut microbiome alterations in cardiometabolic and cardiovascular diseases and the rationale and potential benefit motivating translational approaches to target the gut microbiota and its metabolites for prevention and treatment.
In this Review, the authors summarize the evidence on the different effects of sex and gender on the pathogenesis, clinical manifestations and treatment responses of patients with ischaemic heart disease or heart failure. In addition, they highlight unexplored areas of sex-related and gender-related factors in cardiovascular disease such as in individuals with gender dysphoria.
In this Review, Lutsey and Zakai describe the epidemiology of venous thromboembolism, including incidence, risk factors and outcomes; summarize opportunities for primordial, primary and secondary prevention; and highlight the importance of reducing disparities in venous thromboembolism incidence and management, and opportunities to reduce them.
Originally intended for life-saving salvage therapy, the use of temporary mechanical circulatory support (MCS) devices has become increasingly widespread. In this Review, Salter and colleagues discuss the functionality, indications, management and complications associated with temporary MCS in specific clinical scenarios.
