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An intravascularly infused extracellular matrix preparation binds to leaky microvasculature, thereby localizing to inflamed tissues and promoting repair and regeneration, and potentially healing damaged tissues ‘from the inside out’.
A machine learning model trained using clinical data from electronic health records generated a novel in silico quantitative score for coronary artery disease
A new study shows that age-dependent nuclear remodelling in cardiomyocytes (via age-related loss of nuclear lamins) contributes to cardiac dysfunction through a process that is conserved in flies, mice and nonhuman primates.
In treatment-naive patients with essential hypertension, supplementation with prebiotic acetylated and butyrylated high amylose maize starch significantly reduces systolic blood pressure levels compared with placebo.
A subpopulation of cardiac-resident macrophages protect the heart against sepsis-induced cardiomyopathy by scavenging dysfunctional mitochondria ejected from cardiomyocytes; modulation or administration of these macrophages might be a potential therapeutic strategy.
Cardiopulmonary resuscitation (CPR) provided by a bystander has saved the lives of many patients with out-of-hospital cardiac arrest. Several factors have been hypothesized to contribute to the low rates of bystander CPR, including the race and/or ethnicity of the recipient and the location of the out-of-hospital cardiac arrest.
In this Review, Nattel and colleagues discuss the evidence suggesting a pathophysiological role of cardiomyocyte inflammatory signalling in atrial fibrillation, consider the therapeutic potential associated with these signalling pathways, including strategies promoting the resolution of inflammation, and highlight crucial questions to be addressed in future research.
Advances in machine learning technology in the past decade have accelerated the discovery of genetic loci associated with aortic disease. In this Review, Lindsay and colleagues discuss how emerging insights into the genetic architecture of aortic disease can improve the accuracy of disease prediction and facilitate the discovery of new therapeutic targets.
In this Review, the authors describe the features of coronary artery vulnerable plaques as well as non-invasive and invasive diagnostic modalities that can be used to characterize them. They also discuss the prognostic utility of identifying vulnerable plaques and the best current approaches to manage these lesions, and highlight evidence gaps and future directions.
Advances in single-cell RNA sequencing technologies in the past 5 years have led to a greater understanding of endothelial cell development and heterogeneity. In this Review, Red-Horse and Trimm discuss the most up-to-date research on vascular endothelial cell development and diversity, and highlight the latest findings on organ-specific endothelial cells in the heart, brain, lungs, kidneys and liver.
