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A new study describes the efficacy of novel platelet-mimicking procoagulant nanoparticles in resisting clot lysis and improving clot stability, resulting in reduced bleeding in rodent models of thrombocytopenia and haemorrhage.
Cardiac pacing that restores heart rate variability in the form of respiratory sinus arrhythmia improves outcomes in a sheep model of heart failure with reduced ejection fraction.
Cilia are now known to have broad roles in cardiac development and disease. In this Review, Yuan and colleagues discuss the latest findings that link cilia function and biogenesis to congenital heart disease and describe the role of cilia in the development of cardiac left–right asymmetry, haemodynamic mechanosensation, valvulogenesis and myocardial regeneration.
In this Review, Tao and colleagues discuss the latest advances in nanoparticle-based imaging and therapeutic approaches targeting macrophages in atherosclerotic plaques, highlight opportunities for novel macrophage-targeting nanomedicines for atherosclerosis diagnosis and treatment, and provide solutions to challenges in this area to accelerate clinical translation.
In this Review, Nattel and colleagues discuss the role of cellular senescence in cardiac disease, summarize the therapeutic strategies that are being developed for targeting senescence and consider the potential implications for improving the management of patients with heart disease.
In this Review, Kleinbongard and Heusch characterize the features and mechanisms of coronary microembolization and discuss the clinical trials of drugs and devices for the prevention and treatment of this phenomenon.
