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  • Both rare and common genetic variants predict the onset of cardiovascular disease (CVD), but recent studies have provided compelling evidence that individuals who harbour variants that elevate their risk of CVD can substantially lower this risk by controlling lifestyle-related risk factors, such as smoking, diet, and physical activity.

    • Benoit J. Arsenault
    • Jean-Pierre Després
  • Shared decision-making (SDM) between physicians and patients is a necessary element of care in hypertrophic cardiomyopathy (HCM), particularly for decisions concerning prophylactic implantable defibrillators to prevent sudden death; however, SDM has much less relevance in making eligibility versus disqualification decisions for competitive athletes with HCM.

    • Barry J. Maron
    • Rick A. Nishimura
    • Martin S. Maron
  • Sharing of data from clinical trials provides the opportunity to improve the value and integrity of data analyses, but there are risks, and the primary duty for responsible reporting should reside with the investigators.

    • Christopher B. Granger
    • E. Magnus Ohman