Browse Articles

  • News & Views |

    Cardiovascular disease and cancer share several risk factors. Patients with heart failure have a higher rate of cancer than healthy control populations. Meijers and colleagues have taken this association a step further to present new evidence suggesting that, beyond simply sharing root causes, heart failure might actually cause cancer.

    • A. Mark Richards
  • Review Article |

    This Review summarizes the current knowledge on the biology and regional variability of the adipose tissue, highlighting the molecular mechanisms controlling the crosstalk between the adipose tissue and the cardiovascular system. Current state-of-the-art techniques in adipose tissue imaging for cardiovascular risk stratification and the potential of the adipose tissue as a target for the treatment of cardiovascular disease are also described.

    • Evangelos K. Oikonomou
    •  & Charalambos Antoniades
  • Review Article |

    In this Review, de la Pompa and colleagues describe the role of the Notch pathway during the differentiation and patterning of cardiac tissues and in valve and ventricular chamber development, discussing the crosstalk with other signalling pathways, how defective Notch signalling is linked to congenital heart diseases, and the relevance of the Notch pathway in heart regeneration and repair.

    • Donal MacGrogan
    • , Juliane Münch
    •  & José Luis de la Pompa
  • Review Article |

    The incidence of atrial fibrillation (AF) and the risk of cognitive impairment both increase with age, and the two pathologies share important risk factors. In this Review, Madhavan and colleagues explore the association and mechanisms of cognitive decline and AF, and discuss potential therapies to prevent cognitive impairment in these patients.

    • Malini Madhavan
    • , Jonathan Graff-Radford
    • , Jonathan P. Piccini
    •  & Bernard J. Gersh
  • Review Article |

    In this Review, Meilhac and Buckingham discuss the origin of cardiac cell populations, their lineage relationships and the genes that regulate their behaviour and differentiation. Characterizing the progenitor cells that form the heart and the gene regulatory networks controlling their deployment is of major importance for understanding the origin of congenital heart malformations and for developing cardiac regeneration therapies.

    • Sigolène M. Meilhac
    •  & Margaret E. Buckingham
  • Consensus Statement
    | Open Access

    Patients with diabetes mellitus have a prothrombotic status that increases the risk of cardiovascular events and worsens prognosis after these events. In this Consensus Statement, the Working Group on Thrombosis of the Italian Society of Cardiology proposes antithrombotic strategies for patients with diabetes in various cardiovascular settings.

    • Giuseppe Patti
    • , Ilaria Cavallari
    • , Felicita Andreotti
    • , Paolo Calabrò
    • , Plinio Cirillo
    • , Gentian Denas
    • , Mattia Galli
    • , Enrica Golia
    • , Ernesto Maddaloni
    • , Rossella Marcucci
    • , Vito Maurizio Parato
    • , Vittorio Pengo
    • , Domenico Prisco
    • , Elisabetta Ricottini
    • , Giulia Renda
    • , Francesca Santilli
    • , Paola Simeone
    •  & Raffaele De Caterina
  • News & Views |

    A wealth of data that culminated in a large clinical trial established that IL-1β blockade has beneficial effects in atherosclerotic cardiovascular disease. A new study in gene-targeted mice challenges this view by showing atheroprotective effects of IL-1β.

    • Göran K. Hansson
  • Comment |

    Pacemaker therapy is inaccessible to most patients with bradycardia in Africa. Use of reconditioned pacemakers has been proposed as a safe, efficacious, and ethical means of delivering this therapy. A collaboration between PASCAR, Pace4Life, and Project My Heart Your Heart is working to address this deficit in health care in Africa.

    • Kevin Wunderly
    • , Zaheer Yousef
    • , Aimé Bonny
    • , Kevin J. Weatherwax
    • , Balasundaram Lavan
    • , Craig Allmendinger
    • , Brad Wasserman
    • , George Samson
    • , Sheldon Davis
    • , George Nel
    • , James Russell
    • , Constantine Akwanalo
    • , Mahmoud U. Sani
    • , Ashely Chin
    • , Olujimi A. Ajijola
    • , Bongani M. Mayosi
    • , Kim A. Eagle
    •  & Thomas C. Crawford
  • Review Article |

    Over the past 20 years, new insights into cardiovascular immunopathology have shifted the therapeutic focus from lipids to inflammation. In this Review, Duivenvoorden and colleagues discuss recent discoveries in the immunopathology of atherosclerosis, advances in bioengineering techniques, and how these advances have guided the development of innovative nanoimmunotherapeutic strategies to modulate immune responses in cardiovascular disease.

    • Raphaël Duivenvoorden
    • , Max L. Senders
    • , Mandy M. T. van Leent
    • , Carlos Pérez-Medina
    • , Matthias Nahrendorf
    • , Zahi A. Fayad
    •  & Willem J. M. Mulder
  • Comment |

    Despite substantial advances, bona fide regeneration of the damaged human heart is still an unmet ambition. By extracting our current knowledge from developmental biology, animal models of heart regeneration, and clinical observations, we propose five hallmarks of cardiac regeneration and suggest a holistic approach to reconstituting human heart function.

    • Alessandro Bertero
    •  & Charles E. Murry
  • Review Article |

    Research on cardiac repair and regeneration is shifting from a stem cell focus towards the dynamic interplay of stromal and immune cells of the cardiac interstitium. This Review provides new insights into the immunoregulatory functions of cardiac interstitial cells and their complex network of interactions, highlighting the therapeutic potential for cardiac disease.

    • Elvira Forte
    • , Milena Bastos Furtado
    •  & Nadia Rosenthal
  • Review Article |

    Mitochondrial dysfunction has a major role in the pathogenesis of multiple cardiovascular disorders. In this Review, Galluzzi and colleagues discuss the therapeutic potential of mitochondria-targeting agents in the treatment of cardiovascular disease, examine the obstacles that have limited their development thus far, and identify strategies for the development of these promising therapeutic tools.

    • Massimo Bonora
    • , Mariusz R. Wieckowski
    • , David A. Sinclair
    • , Guido Kroemer
    • , Paolo Pinton
    •  & Lorenzo Galluzzi
  • Review Article |

    The benefits of regular exercise extend beyond its effect on cardiovascular disease (CVD) risk factors. In this Review, the authors outline the non-traditional mechanisms underlying the benefits of exercise in CVD and highlight the importance of a holistic view of exercise in cardiovascular health.

    • Carmen Fiuza-Luces
    • , Alejandro Santos-Lozano
    • , Michael Joyner
    • , Pedro Carrera-Bastos
    • , Oscar Picazo
    • , José L. Zugaza
    • , Mikel Izquierdo
    • , Luis M. Ruilope
    •  & Alejandro Lucia
  • Review Article |

    This Review summarizes the current understanding on the roles of the Hippo–YAP pathway in cardiac development, growth, homeostasis, disease, and regeneration, with a particular focus on the roles of the Hippo–YAP pathway in endogenous cardiac muscle renewal, including the pivotal role of this pathway in regulating cardiomyocyte proliferation, differentiation, stress response, and mechanical signalling.

    • Jun Wang
    • , Shijie Liu
    • , Todd Heallen
    •  & James F. Martin
  • Review Article |

    Inflammageing is a chronic, pro-inflammatory state that develops with age and is a risk factor for cardiovascular disease, comorbidities, frailty, and death. In this Review, Ferrucci and Fabbri discuss whether therapies to modulate inflammageing can reduce the age-related decline in health.

    • Luigi Ferrucci
    •  & Elisa Fabbri
  • Comment |

    Life expectancy around the world has increased steadily for nearly 200 years. This Focus Issue of Nature Reviews Cardiology features five insightful Review articles that describe numerous facets of the latest research on cardiovascular ageing.

    • Edward G. Lakatta
  • Review Article |

    Various intrinsic and extrinsic factors influence the balance between cellular renewal and senescence in the ageing heart. In this Review, Gude and colleagues discuss these factors, including environment, lifestyle, genetics and epigenetics, inflammation, and oxidative stress, and how they might be therapeutically targeted.

    • Natalie A. Gude
    • , Kathleen M. Broughton
    • , Fareheh Firouzi
    •  & Mark A. Sussman
  • Review Article |

    Alterations in mitochondrial function, which are amplified by defective mitochondrial quality control (MQC) mechanisms, are major contributing factors to cardiac senescence. In this Review, the authors discuss the mechanisms linking defective MQC to organelle dysfunction in the context of cardiac ageing and consider how these pathways might be targeted for the prevention and treatment of age-related heart dysfunction.

    • Anna Picca
    • , Robert T. Mankowski
    • , Jonathon L. Burman
    • , Luca Donisi
    • , Jae-Sung Kim
    • , Emanuele Marzetti
    •  & Christiaan Leeuwenburgh
  • News & Views |

    The KardiaBand, which records a rhythm strip from an AppleWatch, was paired with an app for automated detection of atrial fibrillation. A new study by Bumgarner and colleagues is one of the first studies to examine the feasibility of using a smartwatch to discriminate between sinus rhythm and atrial fibrillation.

    • Ki H. Chon
    •  & David D. McManus
  • Review Article |

    Familial hypercholesterolaemia (FH) is the most commonly encountered genetic condition that predisposes to premature cardiovascular disease. In this Review, Berberich and Hegele revisit the genetic complexity of FH and discuss our revised understanding of the mechanisms of FH and the implications for screening, diagnosis, and patient management.

    • Amanda J. Berberich
    •  & Robert A. Hegele
  • Review Article |

    In this Review, a panel of leading experts in antithrombotic pharmacotherapy discuss the principles guiding the role of acetylsalicylic acid (aspirin)-free strategies in the prevention and management of cardiovascular disease, along with their implications for clinical trial design and development.

    • Davide Capodanno
    • , Roxana Mehran
    • , Marco Valgimigli
    • , Usman Baber
    • , Stephan Windecker
    • , Pascal Vranckx
    • , George Dangas
    • , Fabiana Rollini
    • , Takeshi Kimura
    • , Jean-Philippe Collet
    • , C. Michael Gibson
    • , Philippe Gabriel Steg
    • , Renato D. Lopes
    • , Hyeon-Cheol Gwon
    • , Robert F. Storey
    • , Francesco Franchi
    • , Deepak L. Bhatt
    • , Patrick W. Serruys
    •  & Dominick J. Angiolillo