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  • Infection with Trypanosoma spp. can cause Chagas disease or human African trypanosomiasis. In this Review, Sabino and colleagues discuss the effects of these infections on the heart, with particular emphasis on the pathogenesis, diagnosis and treatment of Chagas cardiomyopathy.

    • Ester Cerdeira Sabino
    • Maria Carmo P. Nunes
    • Antonio Luiz P. Ribeiro
    Review Article
  • In this Review, Wu and co-workers describe the consequences of radiation exposure on the cardiovascular system, drawing insights from individuals exposed to whole-body radiation (including nuclear and medical workers) and from patients with cancer undergoing radiation therapy.

    • James W. S. Jahng
    • Mark P. Little
    • Joseph C. Wu
    Review Article
  • In this Review, Catapano and colleagues discuss the evidence supporting the LDL cumulative exposure hypothesis and how measuring cumulative LDL exposure can be used to estimate risk and contribute to the prevention of atherosclerotic cardiovascular disease.

    • Brian A. Ference
    • Eugene Braunwald
    • Alberico L. Catapano
    Review Article
  • Preliminary experience with the use of transcatheter aortic valve implantation (TAVI) to treat non-calcific aortic regurgitation has raised concerns about the short-term effectiveness of TAVI in this setting. A deeper understanding of the interaction between transcatheter heart valves and anatomy in patients with non-calcific aortic valve disease, coupled with the introduction of dedicated TAVI devices, is providing new opportunities in the management of this condition.

    • Marco Barbanti
    • Giulia Laterra
    • Francesco Maisano
    Clinical Outlook
  • In this Review, Porsch and Binder discuss the evidence for and mechanisms of the increased and premature risk of atherosclerotic cardiovascular disease in patients with autoimmune disease, with particular focus on systemic lupus erythematosus and rheumatoid arthritis.

    • Florentina Porsch
    • Christoph J. Binder
    Review Article
  • In this Review, Khan and colleagues explore the evolving global epidemiology of heart failure (HF), focusing on changes in incidence and prevalence across the spectrum of left ventricular ejection fraction. The authors highlight the disparities in our understanding of HF epidemiology in low-income and middle-income countries, affirming the need for improved surveillance and resource allocation in vulnerable areas and populations.

    • Muhammad Shahzeb Khan
    • Izza Shahid
    • Javed Butler
    Review Article
  • The advent of pulsed-field ablation — a series of ultra-rapid, high-energy pulses that result in non-thermal cell death via electroporation — is revolutionizing the field of atrial fibrillation ablation. Data on first iterations of the technology indicate that safety and efficacy are at least similar to that of thermal ablation but with meaningfully shorter procedure duration.

    • Leonid Maizels
    • Jonathan M. Kalman
    Clinical Outlook
  • In this Tools of the Trade article, Jablonska describes the use of proximity-based labelling for the proteomic profiling of novel protein–protein interactions.

    • Zuzanna Jablonska
    Tools of the Trade
  • Findings from a new study published in Science Immunology suggest that epigenetic changes in haematopoietic stem cells promote the production of pro-inflammatory macrophages and influence their capacity to generate protective macrophage subsets.

    • Karina Huynh
    Research Highlight
  • Data from the phase IIb MUIR and ARCHES-2 trials show that RNA interference approaches that target either apolipoprotein C-III or ANGPTL3 significantly reduce plasma triglyceride levels in patients with mixed hyperlipidaemia.

    • Gregory B. Lim
    Research Highlight
  • Haemophilia A is caused by variants in the gene that encodes coagulation factor VIII (FVIII). Sequencing of this gene in the 1980s was the initial step in developing replacement therapy with recombinant FVIII, and thereby removing the risk of blood-borne infections from plasma-derived FVIII.

    • Daisy Jones
    Journal Club
  • Corey McAleese describes the study that identified the presence of metabolic heterogeneity in endothelial cells from different tissues and discusses its relevance to our current understanding of endothelial metabolism.

    • Corey McAleese
    Journal Club
  • Milda Folkmanaite and Manuela Zaccolo highlight a study that demonstrates a role for phase-separated condensates of protein kinase A in buffering molecules of cAMP, to illustrate how phase separation of proteins in cardiac cells might contribute to the regulation of cardiac function.

    • Milda Folkmanaite
    • Manuela Zaccolo
    Journal Club
  • A study in Nature describes a single-cell-type strategy for vascular cell therapies that involves the artificial transplantation of mitochondria to endothelial cells, which promotes mitophagy and facilitates the formation of functional vessels in ischaemic tissue without the need for mesenchymal stromal cell support.

    • Karina Huynh
    Research Highlight
  • Activation of the bile acid receptor TGR5 inhibits CD36-mediated fatty acid uptake in cardiomyocytes and protects against cardiac lipotoxicity and the development of diabetic cardiomyopathy in mice, according to a new study.

    • Irene Fernández-Ruiz
    Research Highlight