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  • The proportion of female cardiologists is increasing in China, and they have special roles in clinical management and research. As the president of the Chinese Society of Cardiology, I believe female cardiologists excel in finding ways to balance family life with their career goals when they receive adequate support.

    • Yaling Han
    World View
  • In this Review, the authors describe the features of coronary artery vulnerable plaques as well as non-invasive and invasive diagnostic modalities that can be used to characterize them. They also discuss the prognostic utility of identifying vulnerable plaques and the best current approaches to manage these lesions, and highlight evidence gaps and future directions.

    • Prakriti Gaba
    • Bernard J. Gersh
    • Gregg W. Stone
    Review Article
  • As a Brazilian female cardiologist who has held leadership positions since my 40s, I understand the difficulties that women face in trying to achieve recognition and senior positions. I believe the awareness and joint efforts of both women and men can help build a more equitable future.

    • Andréa A. Brandão
    World View
  • Advances in machine learning technology in the past decade have accelerated the discovery of genetic loci associated with aortic disease. In this Review, Lindsay and colleagues discuss how emerging insights into the genetic architecture of aortic disease can improve the accuracy of disease prediction and facilitate the discovery of new therapeutic targets.

    • Elizabeth Chou
    • James P. Pirruccello
    • Mark E. Lindsay
    Review Article
  • Among patients in a coma after resuscitation for out-of-hospital cardiac arrest, a restrictive versus liberal oxygenation strategy, or a target mean arterial blood pressure of 77 mmHg versus a target of 63 mmHg, did not affect the risk of neurological disability or death.

    • Karina Huynh
    Research Highlight
  • In the SECURE trial, a polypill containing aspirin, ramipril and atorvastatin taken within 6 months after myocardial infarction reduces the risk of major adverse cardiovascular events compared with usual care.

    • Karina Huynh
    Research Highlight
  • Globally, Black people have some of the highest rates of cardiovascular disease. Racial inequities in cardiovascular health must be tackled. Black In Cardio is a trainee-led initiative aimed at promoting Black people in the cardiovascular field and raising awareness about issues related to the cardiovascular health of Black communities.

    • Jason Amartey
    • Chichi Okagbue
    • Debora Kamin Mukaz
    Comment
  • In patients with heart failure (HF) with mildly reduced or preserved ejection fraction, the SGLT2 inhibitor dapagliflozin reduces the risk of worsening HF or cardiovascular death by 18%, reduces total HF events and cardiovascular deaths by 23% and improves HF symptoms, according to findings from the DELIVER trial.

    • Irene Fernández-Ruiz
    Research Highlight
  • Extravascular implantable cardioverter–defibrillators are safe and effective at detecting and terminating ventricular arrhythmias induced at the time of implantation.

    • Gregory B. Lim
    Research Highlight
  • An invitation to undergo comprehensive cardiovascular screening in men aged 65–74 years did not lower the incidence of death from any cause after 5 years in the DANCAVAS trial, but data suggest benefits in some outcomes and in reducing mortality in men aged < 70 years.

    • Irene Fernández-Ruiz
    Research Highlight
  • In this Review, Nattel and colleagues discuss the evidence suggesting a pathophysiological role of cardiomyocyte inflammatory signalling in atrial fibrillation, consider the therapeutic potential associated with these signalling pathways, including strategies promoting the resolution of inflammation, and highlight crucial questions to be addressed in future research.

    • Dobromir Dobrev
    • Jordi Heijman
    • Stanley Nattel
    Review Article
  • In this Review, McGarrah and White outline the major factors regulating branched-chain amino acid (BCAA) abundance and metabolic fate, highlight molecular mechanisms connecting impaired BCAA homeostasis to cardiovascular disease and discuss the epidemiological evidence connecting BCAAs with various cardiovascular disease states.

    • Robert W. McGarrah
    • Phillip J. White
    Review Article
  • In this Review, Fischmeister and colleagues describe cAMP and cGMP signalling in cardiomyocytes and summarize the various phosphodiesterase (PDE) families expressed in the heart and how they are modified in heart failure. They also assess the potential use of inhibitors or activators of specific PDEs to treat heart failure.

    • Rima Kamel
    • Jérôme Leroy
    • Rodolphe Fischmeister
    Review Article