• A diverse group of people

    This ongoing Series of articles highlights the importance of a more diverse, equitable and inclusive cardiovascular workforce in improving the quality of patient care and scientific research.

  • Computer circuit board representing metabolic pathways

    This ongoing Series of articles from Nature Reviews Cardiology covers all aspects of cardiometabolism, including the role of metabolism in cardiovascular physiology, metabolic remodelling in cardiovascular and cardiometabolic diseases, and novel and potential preventative and therapeutic strategies targeting metabolic pathways.


  • The risk of stroke in patients with atrial high-rate episodes (AHREs) depends on age, comorbidities and AHRE burden. Two randomized clinical trials on the use of oral anticoagulant therapy for stroke prevention in older patients with short and rare AHREs have reported conflicting findings on the efficacy of oral anticoagulation in this patient population, although both trials report a significantly increased risk of major bleeding with oral anticoagulation.

    • Tatjana Potpara
    • Carina Blomstrom-Lundqvist
    Clinical Outlook
  • Representation of Black patients in cardiovascular clinical trials remains dismally low, reflective of systemic and structural barriers, which can lead to missed opportunities to meet community-identified needs, understand responses to medical therapies and improve cardiovascular care. Innovative, multilevel strategies focused on Black communities are warranted to increase enrolment of this population into clinical research.

    • LaPrincess C. Brewer
    • Joshua J. Joseph
  • Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells lose the Y chromosome. Prevalent in haematopoietic cells, this common somatic mutation is associated with decreased longevity and an increased risk of age-related diseases, including cardiovascular disease. Haematopoietic mLOY provides further insight into the sex-specific disparities that exist in disease susceptibility.

    • Soichi Sano
    • Kenneth Walsh
  • Gene therapy involving adenine base editing can correct a pathogenic variant in the Scn5a gene and alleviate arrhythmia phenotypes in a mouse model of long QT syndrome type 3.

    • Irene Fernández-Ruiz
    Research Highlight


Anticoagulant drugs are used to prevent and treat thrombotic disorders in millions of patients worldwide. This Milestone plots the history of anticoagulant drugs, starting with the discovery and clinical trials of heparin and warfarin.


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