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  • Cytotoxic CD8+ T cells specific for the cardiac protein α-myosin heavy chain have a key role in immune-checkpoint-inhibitor-associated myocarditis, according to a study published in Nature.

    • Irene Fernández-Ruiz
    Research Highlight
  • In patients with paroxysmal, untreated atrial fibrillation (AF), first-line cryoballoon ablation is associated with a lower incidence of persistent AF compared with antiarrhythmic drug therapy, according to the 3-year follow-up data from the EARLY-AF trial.

    • Karina Huynh
    Research Highlight
  • In patients with chronic limb-threatening ischaemia who had an adequate conduit for vein bypass, bypass surgery is associated with fewer adverse events or deaths than an endovascular procedure, according to findings from the BEST-CLI trial.

    • Karina Huynh
    Research Highlight
  • The IRONMAN trial adds further support to the known benefits of intravenous iron therapy in patients with heart failure (HF) with reduced ejection fraction and iron deficiency, but narrowly misses the primary end point of hospitalization for HF and cardiovascular death.

    • Irene Fernández-Ruiz
    Research Highlight

Anticoagulants

Anticoagulant drugs are used to prevent and treat thrombotic disorders in millions of patients worldwide. This Milestone plots the history of anticoagulant drugs, starting with the discovery and clinical trials of heparin and warfarin.
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