Nature Reviews Cardiology

Transforming growth factor-β in myocardial disease

Current issue

Invention and uptake of TAVI over the first 20 years

Alain Cribier
World View 31 May 2022
Caffeine consumption and cardiovascular health

Rob M. van Dam
Frank B. Hu
Comment 17 May 2022
Neuroimmune–arterial interfaces regulate atherosclerosis progression

Gregory B. Lim
Research Highlight 16 May 2022
Transforming growth factor-β in myocardial disease

Nikolaos G. Frangogiannis
Review Article 04 Jan 2022
Update on the pathophysiology and medical treatment of peripheral artery disease

Jonathan Golledge
Review Article 07 Jan 2022
Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium

Diana A. Gorog
Robert F. Storey
Richard C. Becker
Consensus Statement 13 Jan 2022

Contents

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Announcements

Focus Issue | Cardiac regulatory mechanisms

This Focus issue of the journal was published in association with the 2022 Gordon Research Conference on 'Cardiac regulatory mechanisms' and features various articles written by conference speakers.
Article Series | Mechanisms of atherosclerosis

This ongoing Series of articles explores the pathophysiological mechanisms of atherosclerosis and the potential for developing novel diagnostic, preventative and therapeutic interventions.
Article Series | Epidemiology of cardiovascular disease

This ongoing Series of articles comprehensively describes the global epidemiology of cardiovascular disease.

Latest Reviews & Analysis

- Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization
  
  In this Roadmap article, international experts summarize the evidence and provide consensus recommendations on the application of transcatheter aortic valve implantation in patients with bicuspid aortic valve anatomy in advance of the anticipated growth in the use of this procedure in this challenging cohort of patients.
  
  Tian-Yuan Xiong
  Walid Ben Ali
  Darren Mylotte
  
  Roadmap 20 Jun 2022
- Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
  
  In this Review, the authors discuss the roles of non-canonical WNT signalling in cardiovascular disease. They provide an overview of non-canonical WNT signalling, describe its links to the pathogenesis of atherosclerosis, heart failure and arrhythmias, and explore the clinical potential of targeting individual components of non-canonical WNT signalling in cardiovascular disease.
  Ioannis Akoumianakis
  Murray Polkinghorne
  Charalambos Antoniades
  
  Review Article 13 Jun 2022
- P2Y₁₂ inhibitor monotherapy in patients undergoing percutaneous coronary intervention
  
  The evolution of stent design has reduced the incidence of stent thrombosis, meaning that the duration of dual antiplatelet therapy after percutaneous coronary intervention (PCI) might be shortened. In this Review, the authors describe the current evidence base and ongoing clinical trials into the use of P2Y₁₂ inhibitor monotherapy after PCI.
  Davide Capodanno
  Usman Baber
  Dominick J. Angiolillo
  
  Review Article 13 Jun 2022
- Climate change and cardiovascular disease: implications for global health
  
  The relationship between climate change and health outcomes is complex. In this Review, Rajagopalan and colleagues describe the environmental exposures associated with climate change and provide an overview of the consequences of climate change, including air pollution and extreme temperatures, on cardiovascular health and disease.
  Haitham Khraishah
  Barrak Alahmad
  Sanjay Rajagopalan
  
  Review Article 07 Jun 2022
- The ongoing quest for the first total artificial heart as destination therapy
  
  In this Review, Kluin and colleagues describe the historical milestones and lessons learned in the development of total artificial hearts (TAHs), discuss the current generation of TAHs and their working mechanisms, and highlight challenges and future perspectives for the field, including new technologies that will promote TAH development in the coming decade.
  Annemijn Vis
  Maziar Arfaee
  Jolanda Kluin
  
  Review Article 06 Jun 2022
- Repurposing drugs to treat cardiovascular disease in the era of precision medicine
  Mena Abdelsayed
  Eric J. Kort
  Mark Mercola
  
  Review Article 23 May 2022
- The need for increased pragmatism in cardiovascular clinical trials
  Muhammad Shariq Usman
  Harriette G. C. Van Spall
  Muhammad Shahzeb Khan
  
  Review Article 17 May 2022
- A roadmap of strategies to support cardiovascular researchers: from policy to practice
  Niamh Chapman
  Emma E. Thomas
  Francine Z. Marques
  
  Roadmap 16 May 2022
- The role of mitochondrial fission in cardiovascular health and disease
  Justin M. Quiles
  Åsa B. Gustafsson
  
  Review Article 06 May 2022

News & Comment

Very high HDL-C levels are associated with higher mortality in patients with CAD

High plasma levels of HDL cholesterol have been shown to be associated with a lower risk of cardiovascular disease. However, paradoxically, very high HDL-cholesterol levels are associated with increased mortality in patients with coronary artery disease, according to a new study.

Irene Fernández-Ruiz
Research Highlight 30 Jun 2022
Piezo1 senses pressure overload and initiates cardiac hypertrophy

The stretch-activated, calcium-permeable Piezo1 channel is the mechanosensor that transduces cardiomyocyte stretch into the biochemical signalling pathway that leads to cardiac hypertrophy in mice.

Gregory B. Lim
Research Highlight 29 Jun 2022
Human susceptibility to coronary artery disease: lessons from chimpanzee resilience

Important lessons about human susceptibility to coronary atherosclerosis can be learned from the relative resilience of chimpanzees to coronary artery disease (CAD), despite their higher baseline plasma levels of LDL cholesterol and lipoprotein(a) than in humans. Evolutionary pressure and hyper-reactive T cells might have a role in the unique susceptibility of humans to CAD.

Gemma A. Figtree
Jason C. Kovacic
Helen M. McGuire
Comment 29 Jun 2022
Inclusion of remnant cholesterol improves risk prediction for ischaemic heart disease

Adding remnant cholesterol levels to traditional risk scores for ischaemic heart disease and myocardial infarction improves the accuracy of individual risk stratification.

Gregory B. Lim
Research Highlight 28 Jun 2022
Gene therapy for Brugada syndrome

Gene therapy targeting the protein trafficking regulator MOG1 successfully reversed clinical features of Brugada syndrome in a knock-in mouse model.

Karina Huynh
Research Highlight 28 Jun 2022
The cardiac parasympathetic system has two parallel circuits

The cardiac parasympathetic nervous system is composed of two parallel circuits with distinct functions: one selectively controls cardiac function and another coordinates cardiac and pulmonary function.

Irene Fernández-Ruiz
Research Highlight 27 Jun 2022

Anticoagulant drugs are used to prevent and treat thrombotic disorders in millions of patients worldwide. This Milestone plots the history of anticoagulant drugs, starting with the discovery and clinical trials of heparin and warfarin.

Milestone 13 Mar 2018