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A specific telomerase inhibitor and several telomerase therapeutic vaccines are in clinical trials, and other telomerase-based therapies are in preclinical development. What are the advantages and disadvantages of these approaches and which cancer patients might benefit most?
Intratumoural hypoxia is a negative prognostic indicator and can underlie therapeutic resistance for many patients. This Review explores the differential biological effects of acute hypoxia versus longer-term, chronic hypoxia on genomic instability and DNA damage repair pathways. What does this mean for therapeutic strategies?
Can we exploit the DNA repair pathways in cancer cells to increase the efficacy of existing and future cancer treatments? This Review discusses the current state of play.
Up to one-third of cancers are due to excess weight and insufficient physical activity. What mechanisms are involved and can physical activity interventions reduce cancer risk?
The family of glycophosphoproteins known as small integrin-binding ligand N-linked glycoproteins (SIBLINGs) are emerging as important players in malignant transformation, invasion and metastasis. Could these proteins be promising diagnostic and prognostic tools, as well as therapeutic targets?
To achieve a comprehensive mechanistic view of the cancer process do we need to assemble a physically integrated team of interdisciplinary scientists that includes mathematicians? This Perspective discusses the useful insights provided by such an interaction.
The discovery that the oncogene MYC can stimulate differentiation rather than proliferation in human epidermal stem cells was, understandably, greeted with scepticism. However, subsequent studies have revealed important concepts that are relevant to the function of MYC in tumorigenesis.
