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Volume 6 Issue 5, May 2006

Volume 6 Issue 5

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From The Editors

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Research Highlight

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In the News

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Research Highlight

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In Brief

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Research Highlight

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Trial Watch

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Research Highlight

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Review Article

  • Both oestrogen and selective oestrogen receptor modulators can promote endometrial carcinogenesis. However, gene-expression studies have shown that they function through distinct, albeit overlapping, mechanisms. This article reviews our current understanding of both pathways.

    • Yongfeng Shang
    Review Article

  • Several ubiquitin ligases are altered in cancer. These proteins are crucial for the ubiquitin-mediated degradation of cell-cycle proteins, ensuring regulated progression through the cycle. Understanding the mechanistic roles of these ligases is therefore of great importance.

    • Keiichi I. Nakayama
    • Keiko Nakayama
    Review Article

  • BRCA1 interacts with many proteins, but one particular protein, BARD1, seems to be an important regulator of BRCA1 function. This review examines whether BARD1 has BRCA1-independent functions that contribute to the pathogenesis of cancer.

    • Irmgard Irminger-Finger
    • Charles Edward Jefford
    Review Article

  • Fibroblasts are an important component of the tumour microenvironment. They become activated in tumours, as they do in healing wounds. Here, their roles in tumour initiation, progression and metastasis are reviewed.

    • Raghu Kalluri
    • Michael Zeisberg

    Collection:

    Review Article
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Opinion

  • Recent data indicate that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might change our understanding of their role in cancer, and do these findings have implications for drug resistance?

    • Charles Massie
    • Ian G. Mills
    Opinion
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Erratum

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