Volume 6 Issue 1, January 2006
From The Editors
In the News
Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer.
This review examines how recent insights, gained from mouse models, have improved our understanding of the contradictory role of adaptive and innate leukocytes in cancer development.
How have the data from the initial clinical trials of histone deacetylase inhibitors (HDACi) improved our understanding of how these drugs work? And what key facts do we still need to understand about the biology of HDACi?
The transcription factors of the Pax gene family are important in growth regulation and, therefore, the prevention of malignant growth. This review examines their roles in embryogenesis and how these can be subverted to contribute to tumorigenesis.
Predicting cancer occurrence is a difficult task. However, if predictions are accurate, they can be useful to health planners trying to optimize resources, and to assess the impact of planned interventions. How are predictions made and what are the challenges?
In the 25 years since Doll and Peto published their groundbreaking report on the causes of cancers and strategies for prevention, there have been many additional epidemiological studies of cancer incidence. What do we now know about opportunities for cancer prevention?
Science and Society
Accessible information about the presence and effect of specific mutations in cancer-causing genes is essential, but keeping track of these mutations is not simple. This article, using p53 as an example, highlights the difficulties involved in maintaining mutation databases.