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Volume 23 Issue 5, May 2023

A personal journey, inspired by the Perspective on p335.

Cover design: Lara Crow.

Research Highlights

  • In this Tools of the Trade article, Francisco Barriga describes the development and use of MACHETE, a flexible deletion engineering strategy, which enables the functional characterization of the large genomic deletions that occur in cancer.

    • Francisco M. Barriga
    Tools of the Trade


  • In this article, Efrat Shema describes EPINUC, a liquid biopsy method based on epigenetic profiling of nucleosomes from cell-free DNA in the plasma. EPINUC, combined with protein biomarker measurements, enables the accurate differentiation of samples from healthy volunteers and patients.

    • Efrat Shema
    Tools of the Trade
  • In this study, Bhardwaj et al. highlight the mechanistic link between elevated body mass index and breast epithelial cell DNA damage in individuals carrying BRCA mutations.

    • Gabrielle Brewer
    Research Highlight
  • In this study, Weems et al. demonstrate that detachment-induced dynamic blebbing leads to the assembly of pro-survival signalling molecules at the plasma membrane, which protects melanoma cells from anoikis.

    • Daniela Senft
    Research Highlight
  • Han et al. employed an in vivo imaging workflow that coupled positron emission tomography imaging to micro-computed tomography and 3D serial block-face electron microscopy to produce a detailed structural and functional map of mitochondrial networks in lung cancer.

    • Anna Dart
    Research Highlight
Top of page ⤴


  • Overactive nucleotide synthesis is a hallmark of cancers and inhibitors of nucleotide synthesis pathways have shown promise in some cancer types. In this Review, Mullen and Singh give an overview of the role of aberrant nucleotide synthesis in supporting cancer cell growth, immune evasion, metastasis and resistance to cancer therapies, with a focus on identifying opportunities for the use of combination therapies to target these pathways more effectively.

    • Nicholas J. Mullen
    • Pankaj K. Singh
    Review Article
  • Knowledge of the native T cell landscape and how it evolves under immunotherapeutic pressure will enable us to improve upon current clinical responses to immune-based interventions. In this Review, Oliveira and Wu outline how recent multidimensional single-cell studies have brought us a step closer to this goal by linking intratumoural phenotypes with the antigen specificity of T cells.

    • Giacomo Oliveira
    • Catherine J. Wu
    Review Article
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  • In this Perspective, Magnon and Hondermarck introduce the emerging field of cancer neuroscience and outline how the bidirectional crosstalk between the brain and peripheral tumours drives cancer development and progression.

    • Claire Magnon
    • Hubert Hondermarck
  • Fibrolamellar hepatocellular carcinoma is a rare cancer type and, as such, research into this disease comes with many challenges. In this Perspective, Sanford Simon tells of his personal journey and experiences in the fight against this rare cancer type.

    • Sanford M. Simon
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