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Complex therapies and multimodal interventions have become the gold standard approach for many of the most aggressive tumour types. However, there is a lack of models that enable the development and clinical translation of such treatment concepts. In this Comment, Saur and Schnieke present an argument for porcine cancer models filling this gap.
Crist et al. set out to investigate what makes the colonization of skeletal muscle by disseminated tumour cells (DTCs) so rare and found that this niche enforces persistent oxidative stress on DTCs that cannot be overcome and therefore, restrains their proliferation.
Reticker-Flynn et al. show that exposure of melanoma cells to interferons and immune cells within lymph nodes leads to immune tolerance that promotes metastasis of both these cells and primary tumour cells.
In this Journal Club, H. Mir and S. Singh discuss a study that established the significance of signalling via the G-protein-coupled receptors CXCR1 and CXCR2 in the extrusion of neutrophil extracellular traps, which can be targeted for cancer therapy.
In this Journal Club, Abbas and Kurian discuss a study showing that using iron selenide quantum dots as biometric probes is superior to conventional organic fluorophores — with higher biocompatibility and quantum yield — in detecting tumour cell growth both in vitro and in vivo.
In this Tools of the Trade article, Ana Luísa Correia describes the development and use of a tracker of dormant disseminated tumour cells to investigate the distribution and dynamics of dormant reservoirs within and across distant sites.
In recent years, research in the field of ferroptosis in cancer has risen steeply in part owing to its potential to be targeted. In this Review, Lei et al. provide an up-to-date synthesis of the roles and mechanisms of ferroptosis in tumour growth and progression, including its function in tumour immunity, highlighting it as a vulnerability that can be exploited for cancer therapy.
This Review provides an overview of cancer-related actions of pattern recognition receptors, including both immune and non-immune functions that influence cancer mechanisms as well as the potential to target pattern recognition receptors for cancer drug development and biomarker discovery.
This Review discusses our current understanding of tumour-infiltrating B lymphocytes (TIL-Bs) in human cancers, considering the role of TIL-Bs across the major facets of cancer immunity. The authors also discuss strategies to harness the cell-based and antibody-based effector mechanisms of TIL-Bs to enable a new generation of cancer immunotherapies.
