Volume 20 Issue 1, January 2020

Volume 20 Issue 1

Bringing the brain into focus, inspired by this month’s Focus issue.

Cover design: Lara Crow.


Research Highlights

  • Research Highlight |

    Strickley, Messerschmidt et al. show that beta human papilloma virus (β-HPV) infection itself is not causal in cutaneous squamous cell carcinoma (SCC) development in the context of immunosuppression — instead, the loss of β-HPV-mediated T cell immunity promotes SCC.

    • Ulrike Harjes
  • Research Highlight |

    Two papers report the discovery and preclinical analyses of two different covalent inhibitors of KRAS-G12C (AMG 510 and MRTX849) as well as the first data on the efficacy of these inhibitors in cancer patients.

    • Sarah Seton-Rogers


  • Viewpoint |

    In this Viewpoint article, we asked four experts to provide their opinions on important aspects of brain metastasis biology, focusing on the unique microenvironment and therapeutic targets in the brain, preclinical models and how studying brain metastases could inform primary brain tumour biology.

    • Adrienne Boire
    • , Priscilla K. Brastianos
    • , Livia Garzia
    •  & Manuel Valiente



  • Review Article |

    This Review discusses how advances in our understanding of the immune system within the brain have implications for the successful implementation of immunotherapy to treat brain tumours, despite challenges such as effective delivery, target specificity and intratumour heterogeneity.

    • John H. Sampson
    • , Michael D. Gunn
    • , Peter E. Fecci
    •  & David M. Ashley


  • Review Article |

    This Review discusses recent genomic, epigenomic, transcriptomic and proteomic profiling studies of human medulloblastoma that have advanced our understanding of its disease subgroups. These efforts have provided new insights into the diverse biology of medulloblastomas that will hopefully lead to improved diagnosis and therapy.

    • Volker Hovestadt
    • , Olivier Ayrault
    • , Fredrik J. Swartling
    • , Giles W. Robinson
    • , Stefan M. Pfister
    •  & Paul A. Northcott


  • Review Article |

    This Review discusses altered cellular metabolism in gliomas, with particular regard to the interaction between tumour genotype and the brain microenvironment, and how advances in studying glioma metabolism have contributed to the discovery of potential drug targets.

    • Junfeng Bi
    • , Sudhir Chowdhry
    • , Sihan Wu
    • , Wenjing Zhang
    • , Kenta Masui
    •  & Paul S. Mischel