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Volume 20 Issue 1, January 2020

Bringing the brain into focus, inspired by this month’s Focus issue.

Cover design: Lara Crow.

Editorial

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Research Highlights

  • Strickley, Messerschmidt et al. show that beta human papilloma virus (β-HPV) infection itself is not causal in cutaneous squamous cell carcinoma (SCC) development in the context of immunosuppression — instead, the loss of β-HPV-mediated T cell immunity promotes SCC.

    • Ulrike Harjes
    Research Highlight
  • Two papers report the discovery and preclinical analyses of two different covalent inhibitors of KRAS-G12C (AMG 510 and MRTX849) as well as the first data on the efficacy of these inhibitors in cancer patients.

    • Sarah Seton-Rogers
    Research Highlight
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Viewpoint

  • In this Viewpoint article, we asked four experts to provide their opinions on important aspects of brain metastasis biology, focusing on the unique microenvironment and therapeutic targets in the brain, preclinical models and how studying brain metastases could inform primary brain tumour biology.

    • Adrienne Boire
    • Priscilla K. Brastianos
    • Manuel Valiente

    Focus:

    Viewpoint
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Reviews

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