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In this Comment, the author, a cancer researcher and breast cancer survivor, discusses her experience as a patient with cancer and how it influenced her approach to research.
Ombrato et al. developed a fluorescent labelling system, which uses metastatic cells themselves to directly mark neighbouring cells in vivo and revealed the lung parenchyma to be a previously unrecognized component of the metastatic niche.
In a study published in Cell, Dong et al. employ a genome-scale CRISPR screening approach to identify both known and previously uncharacterized regulators of CD8+ T cell activity, highlighting the utility of this approach for immunotherapeutic target discovery.
Rivadeneira et al. show that treatment of melanoma-bearing mice with the oncolytic Vaccinia virus recruits metabolically dysfunctional CD8+ T cells, which limits tumour regression. Vaccinia-mediated engineered expression of leptin in cancer cells improved responses through metabolic reprogramming of T cells.
Using high-resolution proteomics to analyse clinical samples from patients with advanced melanoma, Harel et al. show that the metabolic state of melanoma is associated with changes in antigen presentation-related proteins and thereby with response to immunotherapies.
O’Connor et al. show that gliosis in the brain contributes to the development of central nervous system lymphomas (CNSLs) through the production of the chemokine CCL19 by astrocytes, which in turn promotes CNSL cell retention in the brain.
Morris IV et al. adapted a mouse model of human pancreatic ductal adenocarcinoma and found that p53-dependent metabolic changes restrain tumour progression through α-ketoglutarate accumulation and promotion of a premalignant cell fate.
This Review discusses the various approaches that are being explored to target transcription factors in cancer, with many of the inhibitors developed from such approaches now advancing to early clinical trials.
Methionine uptake and metabolism contributes to cancer pathogenesis through functions in methylation reactions and one-carbon metabolism. This Review discusses methionine metabolism in the context of nutrition and the potential of targeting methionine metabolism in cancer through dietary or pharmacological intervention.
This Analysis article examines the extent of genetic heterogeneity within several types of untreated cancers, with particular regard to its clinical relevance, and finds that the homogeneity of predicted functional mutations in driver genes is the rule rather than the exception.
This Opinion discusses the effects of dietary factors on tumour growth and progression through changes in nutrient availability and metabolism, proposing an experimental framework for the investigation of the connections between diet and tumour metabolism.
