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Volume 18 Issue 6, June 2018

‘Locking down oestrogen receptors’ inspired by the Perspective on p377

Cover design: Carl Conway

Research Highlights

  • Whether lymph node metastases can be a source of cancer cells for distant metastases has been debated. Now, two studies have used mouse models to show that tumour cells can colonize distant organs by invading lymph node blood vessels.

    • Anna Dart
    Research Highlight


  • Wang et al. have developed a diagnostic tool (based on the widely used Papanicolaou (Pap) test) to detect endometrial and ovarian cancer in patients by using PCR-based analyses of genetic mutations and aneuploidy.

    • Ulrike Harjes
    Research Highlight
  • Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.

    • Sarah Seton-Rogers
    Research Highlight
  • Han et al. have identified a new tumour-induced immune cell population in the spleen that can promote tumour growth through production of the neurotrophic factor artemin.

    • Anna Dart
    Research Highlight
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  • The MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.

    • Paolo M. Comoglio
    • Livio Trusolino
    • Carla Boccaccio
    Review Article
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  • In this Timeline article, Maman and Witz describe how much progress has been made in understanding how the tumour microenvironment influences tumour progression since its initial description, highlighting the controversies in the field and the potential of targeting components of the microenvironment for cancer therapy.

    • Shelly Maman
    • Isaac P. Witz
  • This Opinion article highlights how activating mutations in the gene encoding oestrogen receptor-α (ERα), a major driver in breast cancer, undermine structural features of wild-type ERα that maintain the ‘off-state’ in the absence of oestrogens, thus making ERα constitutively active and endocrine-therapy resistant.

    • John A. Katzenellenbogen
    • Christopher G. Mayne
    • Sarat Chandarlapaty
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