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Volume 18 Issue 1, January 2018

'Patchwork fields'. Image Source/Alamy Stock Photo, inspired by the Review on p19.

Research Highlight

  • The gut microbiome can modulate the clinical response to anti-programmed cell death protein 1 (PD1) immunotherapy in patients with solid tumours.

    • Anna Dart
    Research Highlight

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  • New research published inNaturenow demonstrates that immune checkpoint blockade can alleviate hepatocellular carcinoma progression in patients with nonalcoholic steatohepatitis (NASH) by inhibiting immunosuppressive immunoglobulin A-producing cells in the liver.

    • Ulrike Harjes
    Research Highlight
  • Alvarez, Sviderskiyet al. have identified a pathway that allows primary lung tumour cells or lung metastatic breast tumour cells to survive in the high oxygen concentrations present in the lung.

    • Sarah Seton-Rogers
    Research Highlight
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Review Article

  • Non-coding RNAs (ncRNAs) are functional molecules that regulate physiological programmes in developmental and disease contexts. This Review article discusses the complex networks of interactions that ncRNAs engage in and how these confer oncogenic or tumour-suppressive effects in cancer.

    • Eleni Anastasiadou
    • Leni S. Jacob
    • Frank J. Slack
    Review Article
  • Field cancerization underlies the development of many types of cancer. This Review examines the biological mechanisms that drive the evolution of cancerized fields and discusses how measuring field evolution could improve cancer risk prediction in patients with pre-malignant disease.

    • Kit Curtius
    • Nicholas A. Wright
    • Trevor A. Graham

    Series:

    Review Article
  • Sphingolipids, specifically ceramide and sphingosine-1-phosphate, have opposing roles in regulating cancer cell death and survival, respectively. This Review discusses the mechanistic and clinical studies of sphingolipid signalling and metabolism in cancer, highlighting current and emerging therapeutic strategies to target these bioactive lipids.

    • Besim Ogretmen
    Review Article
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Opinion

  • Causal associations have been established between dysregulated ribosome biogenesis and cancer. In this Opinion article, the authors highlight emerging mechanistic data on the molecular basis of ribosomes in cancer and offer their perspective on how these advances present therapeutic opportunities.

    • Joffrey Pelletier
    • George Thomas
    • Siniša Volarević
    Opinion
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