Volume 17 Issue 10, October 2017

Volume 17 Issue 10

'Exercise through yoga' by Carl Conway, inspired by the Perspective on p620.

Editorial

  • Editorial |

    This issue marks the publication of a Consensus Statement that proposes a classification system for the evolutionary and ecological features of cancers.

Research Highlights

  • Research Highlight |

    Vitamin C supplementation has shown limited benefits in patients with solid tumours. Two studies report that vitamin C supplementation can reduce Tet-dependent leukaemia progression in mice, supporting the concept of high-dose vitamin C supplementation in certain patients with haematological malignancies.

    • Ulrike Harjes
  • Research Highlight |

    Although speckle-type POZ protein (SPOP) is the most frequently mutated gene in primary prostate cancer, its therapeutic implications are incompletely understood. Now, three studies describe mechanisms of resistance to bromodomain and extraterminal (BET) protein inhibitors in SPOP-mutated prostate cancer.

    • Conor A. Bradley
  • Research Highlight |

    Using DNA barcoding, Lan et al. investigated the clonal evolution and dynamics of glioblastoma cells, and propose a model whereby proliferative heterogeneity is derived from stochastic fate decisions made by a homogeneous population of glioblastoma stem cells and their progeny.

    • Conor A. Bradley
  • In Brief

Reviews

Consensus Statement

  • Consensus Statement | | open

    Based on a consensus conference of experts in the evolution and ecology of cancer, this article proposes a framework for classifying tumours that includes four evolutionary and ecological processes: neoplastic cell diversity and changes over time in that diversity, hazards to cell survival and available resources.

    • Carlo C. Maley
    • , Athena Aktipis
    • , Trevor A. Graham
    • , Andrea Sottoriva
    • , Amy M. Boddy
    • , Michalina Janiszewska
    • , Ariosto S. Silva
    • , Marco Gerlinger
    • , Yinyin Yuan
    • , Kenneth J. Pienta
    • , Karen S. Anderson
    • , Robert Gatenby
    • , Charles Swanton
    • , David Posada
    • , Chung-I Wu
    • , Joshua D. Schiffman
    • , E. Shelley Hwang
    • , Kornelia Polyak
    • , Alexander R. A. Anderson
    • , Joel S. Brown
    • , Mel Greaves
    •  & Darryl Shibata

Perspectives

    Opinion

  • Opinion |

    Emerging data indicate that exercise modulates cancer biology and disease outcomes; however, the molecular mechanisms are poorly established. In this Opinion article, the authors speculate on how exercise might reprogramme the tumour microenvironment to influence cancer hallmarks.

    • Graeme J. Koelwyn
    • , Daniela F. Quail
    • , Xiang Zhang
    • , Richard M. White
    •  & Lee W. Jones

Erratum

  • Erratum |

    • Annette T. Byrne
    • , Denis G. Alférez
    • , Frédéric Amant
    • , Daniela Annibali
    • , Joaquín Arribas
    • , Andrew V. Biankin
    • , Alejandra Bruna
    • , Eva Budinská
    • , Carlos Caldas
    • , David K. Chang
    • , Robert B. Clarke
    • , Hans Clevers
    • , George Coukos
    • , Virginie Dangles-Marie
    • , S. Gail Eckhardt
    • , Eva Gonzalez-Suarez
    • , Els Hermans
    • , Manuel Hidalgo
    • , Monika A. Jarzabek
    • , Steven de Jong
    • , Jos Jonkers
    • , Kristel Kemper
    • , Luisa Lanfrancone
    • , Gunhild Mari Mælandsmo
    • , Elisabetta Marangoni
    • , Jean-Christophe Marine
    • , Enzo Medico
    • , Jens Henrik Norum
    • , Héctor G. Palmer
    • , Daniel S. Peeper
    • , Pier Giuseppe Pelicci
    • , Alejandro Piris-Gimenez
    • , Sergio Roman-Roman
    • , Oscar M. Rueda
    • , Joan Seoane
    • , Violeta Serra
    • , Laura Soucek
    • , Dominique Vanhecke
    • , Alberto Villanueva
    • , Emilie Vinolo
    • , Andrea Bertotti
    •  & Livio Trusolino