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Two papers published inNature Geneticshave reported whole-genome and whole-exome sequencing of paired Barrett oesophagus and oesophageal adenocarcinoma (EAC) samples, providing some insights into the development of EAC from its precursor lesion.
Alekseyenko, Walshet al. have discovered that NUT fusion proteins, which underlie the development of the aggressive squamous cell cancer NUT midline carcinoma, localize to very large hyperacetylated domains within chromatin, which they term 'megadomains', leading to aberrant transcriptional programmes that promote tumorigenesis.
A paper published inNature Medicinereports on the results of treating patients with multiple myeloma with engineered T cells that recognise the cancer—testis antigen NY-ESO-1.
Cancer cells exhibit huge phenotypic plasticity, which can lead to adaptations to the tumour microenvironment and therapy. Much of this plasticity seems to be encoded in signal transduction networks, such that alterations in signalling dynamics can affect many cancer-associated phenotypes and therapeutic response.
This Review discusses nucleotide metabolism and how fluctuations in deoxyribonucleoside triphosphate (dNTP) pools affect genomic instability. Drugs that target this system have been in use for many years and some of these are discussed, as well as newer approaches to manipulating deoxyribonucleotide metabolism for cancer treatment.
This Review discusses the importance of glycobiology in cancer research, given its role in cancer development and progression, and provides an overview of possible targets for diagnostic application and therapeutic strategies.
This Opinion describes the early interactions between immune cells and pre-neoplastic cells observed in translucent zebrafish andDrosophila melanogastermodels, and speculates on their potential implications in human cancer.
Activation of the peripheral nervous system can promote metastasis of primary tumours. This Opinion article discusses the molecular mechanisms through which physiological stress can have an effect on cancer, and how pharmacological antagonism of β-adrenergic signalling might represent a therapeutic opportunity to target cancer progression.
