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This paper finds that levels of histone H3 lysine 79 (H3K79) methylation affect the level of gene expression through the AF10–DOT1L complex, with implications for acute myeloid leukaemia therapy.
A screening platform using cell cultures derived from tumour biopsy samples identifies drug combinations that are effective in treating tumour resistance.
Data from three recent papers suggest that alterations of super-enhancers in cancer cells can promote oncogene expression and therapeutic resistance in some cases. Proteins that promote transcription from super-enhancers might be viable therapeutic targets.
Hyperactivation of phosphatidylinositol 3-kinase (PI3K) signalling cascades is one of the most common events in human cancers. This Review discusses recent advances in our knowledge of the roles of distinct PI3K isoforms in normal and oncogenic signalling, and the current state and future potential of targeting this pathway in the clinic.
This Review discusses recent advances in the molecular characterization of bladder cancer, which has provided insights into pathogenesis and subgroups of bladder cancers with different prognosis.
The identification in 1993 of inherited mutations in the von Hippel–Lindau (VHL) gene in families with VHL disease was a seminal finding. This and subsequent discoveries have given the VHLtumour suppressor gene a central role in our understanding of the mechanisms of cellular oxygen sensing and in the pathobiology of clear-cell renal cell carcinoma.
