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Inhibition of macrophage colony-stimulating factor 1 receptor (CSF1R) can block glioblastoma growth by changing the phenotype of tumour-associated macrophages from pro-tumorigenic to antitumorigenic.
Two papers published inCancer Discoveryunveil the molecular mechanisms that underpin the improved response of patients with high-risk prostate cancer to ionizing radiation in the presence of androgen deprivation therapy.
A coordinately published set of papers inNature, Nature Geneticsand other journals report data from up to 5,000 individual cancers, including cancers of the breast, uterus, ovaries, lung, brain, head and neck, colon and rectum, bladder, kidney and blood.
The role of inflammation in tumorigenesis and tumour progression is increasingly coming into focus, and this Review discusses the current ideas about the mechanisms of inflammation-associated tumorigenesis and the association with the microbiota.
In this Review, the authors examine the aetiological, pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases, the clinical outcomes with targeted therapies, and strategies to discover additional kinases that are activated by chromosomal rearrangements in solid tumours.
The influence of the microenvironment on tumour progression is becoming clearer. This Review addresses the role of transforming growth factor-β in the regulation of components of the tumour microenvironment.
There is an emerging association between the microbiota and carcinogenesis. How might the microbiota modulate tumorigenesis, and what do we need to understand to more firmly conclude that the microbiome causes cancer?
This Opinion article outlines the roles of vesicle trafficking pathways in various phenotypes shown by cancer cells, especially loss of polarity and invasion, and argues that although these proteins are not drivers of transformation, they are integral to maintaining neoplastic phenotypes.
