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Volume 10 Issue 12, December 2010

From The Editors

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Research Highlight

  • A complex interdependent regulatory network exists between YAP, ASPP1 and LATS in the control of apoptosis.

    • Mhairi Skinner
    Research Highlight
  • Cytohesins bind to the cytoplasmic domains of dimerized EGFRs and facilitate their activation through formation of asymmetric dimers.

    • Nicola McCarthy
    Research Highlight
  • A MYC-centred network is shown to be responsible for the similarities between ES and cancer cells; and, inDrosophila melanogaster, MYC and the Hippo transcriptional regulator Yorkie regulate each other's expression to control growth.

    • Meera Swami
    Research Highlight
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In Brief

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Research Highlight

  • WT1is shown to be synthetic lethal withKRAS, and loss of WT1 in the context of oncogenic KRASleads to senescence.

    • Meera Swami
    Research Highlight
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In Brief

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Research Highlight

  • Elsa Flores and colleagues find that TAp63 is a haploinsufficient tumour suppressor and a suppressor of metastasis.

    • Gemma K. Alderton
    Research Highlight
  • ARTS, an inhibitor of XIAP, is required for apoptosis in haematopoietic stem and progenitor cells, and loss of ARTS can promote tumour development.

    • Nicola McCarthy
    Research Highlight
  • PDE4 inhibition drives melanogenesis in a mouse model of skin cancer probably by blocking a MITF–PDE4D3 negative feedback loop.

    • Kira Anthony
    Research Highlight
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Trial Watch

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Progress

  • The function of the deacetylase SIRT1 in cancer is complex and controversial. This article discusses the recent progress that has been made in mouse models to address the role of SIRT1 in tumour development.

    • Daniel Herranz
    • Manuel Serrano
    Progress
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Review Article

  • The polo-like kinases and aurora kinases have various roles in mitosis, and inhibitors of these kinases are being tested in clinical trials. Recent data have shown that extensive crosstalk exists between the polo-like kinase and aurora kinase pathways, which might affect the efficacy of these drugs. This Review discusses the biology of these kinases and how drugs that inhibit them might be used in the clinic.

    • Susanne M. A. Lens
    • Emile E. Voest
    • René H. Medema
    Review Article
  • Certain members of the Ras superfamily of small GTPases are commonly deregulated in human cancers, but how can we target them? This Review explores the association of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that regulate GTPases with cancer and discusses whether they can be effectively targeted therapeutically.

    • Dominico Vigil
    • Jacqueline Cherfils
    • Channing J. Der
    Review Article
  • Adaptor (or scaffold) proteins form signalling platforms that regulate downstream signalling events. Evidence suggests that adaptors functioning downstream of integrins and receptor tyrosine kinases are deregulated in cancer and have important roles in mediating tumour cell survival, proliferation and motility.

    • Sara Cabodi
    • Maria del Pilar Camacho-Leal
    • Paola Defilippi
    Review Article
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Opinion

  • The increasing number of cancer survivors has highlighted the problem of tumour dormancy, which can lead to relapse. Preclinical models and initial clinical trials are paving the way to address how best to treat long-term cancer survivors to minimize the risk of late cancer recurrence.

    • Paul E. Goss
    • Ann F. Chambers
    Opinion
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Timeline

  • It has been nearly 100 years since Francis Peyton Rous proved that sarcomatous chest tumours in Plymouth Rock hens could be caused by a virus. Since then, seven human viruses have been found to cause 10–15% of human cancers. This Timeline article explores the different techniques that helped in identifying these viruses, the common features they share and the different ways they evade innate immunity and cause cancer.

    • Patrick S. Moore
    • Yuan Chang
    Timeline
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Corrigendum

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