Latest Research

  • Review Article |

    Clonal expansion in phenotypically normal or non-cancer tissues is commonly seen in association with ageing and/or in response to environmental insults and chronic inflammation, but does not necessarily indicate cancer development. This Review discusses recent findings on clonal expansion in these tissues and their biological significance in cancer development, ageing and inflammatory diseases.

    • Nobuyuki Kakiuchi
    •  & Seishi Ogawa
  • Review Article |

    Alterations in the extracellular matrix at the biochemical, biomechanical, architectural and topographical levels contribute to the development and progression of solid tumours. Our increased understanding of matrix biology is leading to the development of new approaches that co-target the matrix in cancer, including in metastasis.

    • Thomas R. Cox
  • Review Article |

    Histone variants are critical for maintenance of genome integrity, nuclear architecture and cell identity. Emerging evidence implicates histone variants and their dedicated chaperones in cancer initiation and progression; this Review examines the key players, their mechanisms of action and strategies to target these therapeutically.

    • Flávia G. Ghiraldini
    • , Dan Filipescu
    •  & Emily Bernstein
  • Perspective |

    This Perspective outlines the connections of epithelial–mesenchymal transition programmes to the stem cell state in both normal and cancer stem cells and discusses emerging concepts related to the heterogeneous and plastic cell states generated by an epithelial–mesenchymal transition that influence our understanding of cancer stem cell biology and cancer metastasis.

    • Arthur W. Lambert
    •  & Robert A. Weinberg
  • Perspective |

    The number of publications on deep learning for cancer diagnostics is rapidly increasing, but clinical translation is slow. This Perspective advocates performance estimation in external cohorts and strongly advises that a primary analysis is predefined in a standardized protocol preferentially stored in an online repository.

    • Andreas Kleppe
    • , Ole-Johan Skrede
    •  & Håvard E. Danielsen
  • Review Article |

    This Review outlines the major advances that have been made to the efficacy and safety of chimeric antigen receptor (CAR) T cell therapies over the past 3 years and looks to new findings that will have consequences for the future of this immunotherapy.

    • Rebecca C. Larson
    •  & Marcela V. Maus
  • Review Article |

    This Review describes the metabolic rewiring that occurs in cancer cells transitioning through the metastatic cascade and discusses the evidence for metabolically distinct features of primary tumours and metastases.

    • Gabriele Bergers
    •  & Sarah-Maria Fendt
  • Review Article |

    Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in the escape from antitumour immunity in multiple malignancies. This Review discusses the mechanisms by which this signalling affects antitumour immune responses and the potential application of immune-genome precision medicine in this context.

    • Shogo Kumagai
    • , Shohei Koyama
    •  & Hiroyoshi Nishikawa
  • Review Article |

    This Review discusses the diverse facets of cancer biology that are shaped by aneuploidy and highlights the distinct roles of aneuploidy as both a tumour promoter and an anticancer vulnerability.

    • Anand Vasudevan
    • , Klaske M. Schukken
    •  & Jason M. Sheltzer
  • Review Article |

    This Review highlights the different genetic pathways impacted by germline mutations that can lead to the development of familial and sporadic haematological malignancies, with a particular focus on recent advances in acute lymphoblastic leukaemia, acute myeloid leukaemia and myelodysplastic syndromes.

    • Jeffery M. Klco
    •  & Charles G. Mullighan
  • Review Article |

    This Review examines recent developments in the molecular and translational aspects of bladder cancer biology and discusses their current or potential future clinical applications in the management of bladder cancer.

    • Linda Tran
    • , Jin-Fen Xiao
    •  & Dan Theodorescu
  • Review Article |

    The hostile microenvironment of the tumour can disrupt endoplasmic reticulum (ER) homeostasis in cancer cells and infiltrating immune cells to result in a state of ER stress. This Review discusses how ER stress can influence not only the pro-tumoural features of cancer cells but also reprogramme the function of innate and adaptive immune cells, creating vulnerabilities that could be targeted by emerging therapeutic strategies.

    • Xi Chen
    •  & Juan R. Cubillos-Ruiz
  • Review Article |

    This Review discusses protein kinase C (PKC) isoforms in cancer, in particular focusing on their functional properties in the context of tumour suppression or promotion, target validation, PKC pharmacology and therapeutic exploitation.

    • Peter J. Parker
    • , Sophie J. Brown
    •  & Lisa Watson
  • Review Article |

    Platinum chemotherapy agents remain among the most widely used anticancer drugs, but there is still room to maximize their efficacy. This Review discusses newer findings related to sensitivity and resistance to these drugs as well as recent advances in platinum drug development.

    • Sven Rottenberg
    • , Carmen Disler
    •  & Paola Perego
  • Review Article |

    Activation of WNT–β-catenin signalling via mutations is a recurrent driver event in human cancer. In this Review, Bugter et al. discuss the influence of different mutational subsets of WNT tumour suppressor genes on cancer growth, clinical outcomes and treatment approaches.

    • Jeroen M. Bugter
    • , Nicola Fenderico
    •  & Madelon M. Maurice
  • Review Article |

    This Review discusses the metabolic regulation of 2-oxoglutarate-dependent dioxygenases (2OGDDs) and how dysregulation of 2OGDDs in cancer, by genetic aberrations or environmental factors including hypoxia and/or the action of oncometabolites, can contribute to tumour development and growth.

    • Julie-Aurore Losman
    • , Peppi Koivunen
    •  & William G. Kaelin Jr.
  • Review Article |

    This Review discusses how altered processing or activity of coding and non-coding RNAs contributes to cancer, introducing the regulation of gene expression by coding and non-coding RNA and discussing both established and emerging roles for RNAs in cancer.

    • Gregory J. Goodall
    •  & Vihandha O. Wickramasinghe