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Nie et al. performed metabolomics profiling on samples obtained from patients during the development of invasive lung adenocarcinoma and showed that metabolic pathways are progressively disrupted.
Hung, Yost, Xie et al. show that extrachromosomal DNAs (ecDNAs) are held together in hubs in the nucleus and that intermolecular interactions between ecDNAs can enhance oncogene expression.
In this Journal Club, Desiree Rivers discusses a study that developed and assessed the impact of SurvivorSHINE, a web-based lifestyle intervention for cancer survivors.
In this Journal Club, Ashktorab and Brim discuss a study that established consensus molecular subtypes for colorectal cancer (CRC) with potential for direct clinical translation and better classification of CRC.
Liu et al. show that glycogen accumulates in pre-malignant liver cells by undergoing liquid–liquid phase separation and, by sequestering Hippo kinases MST1 and MST2, promotes YAP-driven tumorigenesis.
Kaushik Tiwari et al. have developed a strategy to directly target amplified genes in cancer using triplex-forming oligonucleotides, which selectively induce DNA damage and apoptosis in cancer cells with copy number gains.
Guo et al. have developed a novel strategy, which involves coating tumour cells with silica, to enable personalized cancer vaccines to overcome the immunosuppressive effects of the tumour microenvironment.
Klemm et al. examined the role of tumour-associated macrophages (TAMs) at different stages of brain metastasis in mouse models and found that targeting TAMs by inhibiting both CSF1R and STAT5 might have long-lasting efficacy and prevent resistance.
Pernigoni et al. present a unique mode of non-genetic resistance accounting for castration-resistant prostate cancer that is mediated by androgen-synthesizing gut microbiota.
Neuhöfer et al. have identified a rare subpopulation of pancreatic acinar cells in the exocrine compartment that renews the pancreas by fuelling clonal expansion. When harbouring Kras mutations, these acinar cells accelerated clone formation and might represent an early cancer precursor lesion.
Schneider et al. show that peripheral serotonin augments colorectal and pancreatic tumour growth in mice by increasing PDL1 expression on cancer cells, and in turn inhibiting the accumulation of functional CD8+ T cells within tumours.
Canale et al. engineered the bacterial strain Escherichia coli Nissle 1917 to recycle ammonia into arginine, and showed synergistic responses with anti-programmed cell death 1 ligand 1 therapy in tumour-bearing mice when injected intratumourally or given systemically.
Xu et al. have uncovered a novel and unexpected role for the ERα as a non-canonical RNA-binding protein, which functions to maintain breast cancer cell survival and tamoxifen resistance.
In this Journal Club, Robert L. Copeland and Yasmine Kanaan discuss a paper that reports how ERβ and IGF2 signalling may contribute to the heterogeneity of triple-negative breast cancer observed in patients with different ancestries in the USA.
Two recent studies have found that both the adaptive immune system and inflammation can drive the selection of cells carrying mutations that facilitate tumour initiation.
In an effort to bring to our pages some of the vibrant discussion of cancer research that happens during in-person or online journal club meetings, we are now publishing Journal Clubs — an article type in which researchers discuss research papers of their choice with the intention of alerting our readers to articles that have a special significance to them and the field.
This issue marks the 20th anniversary of Nature Reviews Cancer. On this milestone birthday we both look back on the past 20 years of cancer research and look forward to the future.
Using zebrafish and human pluripotent stem cell-derived models of melanoma, Baggiolini, Callahan et al. demonstrate that cells expressing progenitor-like programmes and specific chromatin-modifying enzymes are more readily transformed by BRAFV600E.
