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Alvarez, Sviderskiyet al. have identified a pathway that allows primary lung tumour cells or lung metastatic breast tumour cells to survive in the high oxygen concentrations present in the lung.
The importance of 'Warburgian' metabolism in cancer is an increasingly disputed topic. By studying cancer metabolism in patients and mouse models, Faubertet al. now show that lactate is used as a respiratory fuel in non-small-cell lung cancer in vivo.
New research published inNaturenow demonstrates that immune checkpoint blockade can alleviate hepatocellular carcinoma progression in patients with nonalcoholic steatohepatitis (NASH) by inhibiting immunosuppressive immunoglobulin A-producing cells in the liver.
Melloet al. analysed the effects of various p53 transactivation domain mutants in pancreatic ductal adenocarcinoma and uncovered a crucial tumour-suppressive pathway in which p53 mediates inhibition of the transcriptional co-activator YAP.
A modular synthetic RNA-based gene circuit has been developed to program tumour cells to express a combination of immunomodulators to improve the specificity and efficacy of cancer immunotherapy.
Sympathetic nerves associate with tumours and regulate the tumour microenvironment. How this innervation promotes tumorigenesis is unclear. A new study in Scienceshows that β-adrenergic signalling controls tumour growth by promoting tumour angiogenesis, through the regulation of vascular metabolism.
Konget al. report a mechanism that underlies tumour 'drug addiction' in melanoma cell lines and mouse models involving an ERK2-dependent phenotype switch, which might have clinical implications for the use of alternating treatment strategies with targeted therapies.
A recent study shows that smoking-induced epigenetic changes in lung epithelium occur even before malignant transformation, and sensitize the cells to allow a single key oncogenic event to initiate the growth of a tumour.
Zhanget al. report that CD8+tumour-infiltrating T lymphocytes exposed to a hypoglycaemic and hypoxic tumour microenvironment enhance PPARα signalling and fatty acid catabolism to partially preserve effector functions and increase the efficacy of immunotherapy in melanoma mouse models.
Using DNA barcoding, Lanet al. investigated the clonal evolution and dynamics of glioblastoma cells, and propose a model whereby proliferative heterogeneity is derived from stochastic fate decisions made by a homogeneous population of glioblastoma stem cells and their progeny.
This issue marks the publication of a Consensus Statement that proposes a classification system for the evolutionary and ecological features of cancers.
