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In this Tools of the Trade article, Isabel Esain-Garcia describes the development and use of a 6-letter whole-genome sequencing technology, which enables the simultaneous acquisition of genetic and epigenetic information from human genomic and cell-free DNA, which has implications for improving our biological understanding of cancer as well as cancer diagnosis and early intervention.
In this Tool of the Trade article, Eva Freckmann describes the development of Traject3d, a workflow that enables the detection of heterogeneous phenotypes in 3D culture by analysing label-free multi-day time-lapse imaging.
In this study, Insco et al. find patient-specific CDK13 mutations to impede RNA surveillance, leading to the accumulation and translation of prematurely terminated RNAs that drive malignancy in melanoma models.
Sloan and colleagues demonstrate that anthracycline chemotherapy drives metastatic progression by stimulating a cancer cell-mediated increase in nerve fibre activity in the tumour microenvironment, which can be reversed by the use of β-blockers.
In a recent study on castration-resistant prostate cancer, Cui et al. uncover a role for cancer-associated fibroblasts (CAFs) in inducing androgen synthesis in prostate cancer cells.
In a recent Nature study, Hill et al. provide mechanistic evidence that air pollution promotes lung tumorigenesis in cells with pre-existing oncogenic mutations.
In this Tools of the Trade article, Zhenqin Wu describes the development and use of SPACE-GM, a graph deep learning tool that enables the detection of spatial cellular structures predictive of outcomes of patients with cancer.
Blanpain and colleagues provide evidence that the small RHO GTPase, RHOJ, mediates resistance to chemotherapy in tumour cells that have undergone epithelial-to-mesenchymal transition by enabling these cells to tolerate replicative stress and promote DNA damage repair.
In this Tool of the Trade article, Tatiana Flisikowska describes the development and use of humanized minipigs that allow the preclinical safety testing of human therapeutic antibodies.
In this Tool of the Trade article, Mateusz Legut describes the development and use of OverCITE-seq, a new single-cell multiomics approach enabling the high-throughput quantification of the transcriptome and surface antigens in cells expressing a library of open reading frames.
In this study, Weems et al. demonstrate that detachment-induced dynamic blebbing leads to the assembly of pro-survival signalling molecules at the plasma membrane, which protects melanoma cells from anoikis.
Han et al. employed an in vivo imaging workflow that coupled positron emission tomography imaging to micro-computed tomography and 3D serial block-face electron microscopy to produce a detailed structural and functional map of mitochondrial networks in lung cancer.
In this Tools of the Trade article, Alexandros P. Drainas describes the development and use of EpicMIBI, a multiplexed imaging technology that enables the study of spatial clonality in cancer.
In this study, Bhardwaj et al. highlight the mechanistic link between elevated body mass index and breast epithelial cell DNA damage in individuals carrying BRCA mutations.
In this article, Efrat Shema describes EPINUC, a liquid biopsy method based on epigenetic profiling of nucleosomes from cell-free DNA in the plasma. EPINUC, combined with protein biomarker measurements, enables the accurate differentiation of samples from healthy volunteers and patients.
In this Tools of the Trade article, Francisco Barriga describes the development and use of MACHETE, a flexible deletion engineering strategy, which enables the functional characterization of the large genomic deletions that occur in cancer.
