News & Comment

Filter By:

  • Kaushik Tiwari et al. have developed a strategy to directly target amplified genes in cancer using triplex-forming oligonucleotides, which selectively induce DNA damage and apoptosis in cancer cells with copy number gains.

    • Anna Dart
    In Brief
  • Guo et al. have developed a novel strategy, which involves coating tumour cells with silica, to enable personalized cancer vaccines to overcome the immunosuppressive effects of the tumour microenvironment.

    • Anna Dart
    In Brief
  • Klemm et al. examined the role of tumour-associated macrophages (TAMs) at different stages of brain metastasis in mouse models and found that targeting TAMs by inhibiting both CSF1R and STAT5 might have long-lasting efficacy and prevent resistance.

    • Sarah Seton-Rogers
    Research Highlight
  • Pernigoni et al. present a unique mode of non-genetic resistance accounting for castration-resistant prostate cancer that is mediated by androgen-synthesizing gut microbiota.

    • Anna Dart
    Research Highlight
  • Neuhöfer et al. have identified a rare subpopulation of pancreatic acinar cells in the exocrine compartment that renews the pancreas by fuelling clonal expansion. When harbouring Kras mutations, these acinar cells accelerated clone formation and might represent an early cancer precursor lesion.

    • Linda Gummlich
    Research Highlight
  • Schneider et al. show that peripheral serotonin augments colorectal and pancreatic tumour growth in mice by increasing PDL1 expression on cancer cells, and in turn inhibiting the accumulation of functional CD8+ T cells within tumours.

    • Anna Dart
    In Brief
  • Canale et al. engineered the bacterial strain Escherichia coli Nissle 1917 to recycle ammonia into arginine, and showed synergistic responses with anti-programmed cell death 1 ligand 1 therapy in tumour-bearing mice when injected intratumourally or given systemically.

    • Ulrike Harjes
    Research Highlight
  • Xu et al. have uncovered a novel and unexpected role for the ERα as a non-canonical RNA-binding protein, which functions to maintain breast cancer cell survival and tamoxifen resistance.

    • Anna Dart
    In Brief
  • In this Journal Club, Robert L. Copeland and Yasmine Kanaan discuss a paper that reports how ERβ and IGF2 signalling may contribute to the heterogeneity of triple-negative breast cancer observed in patients with different ancestries in the USA.

    • Robert L. Copeland
    • Yasmine Kanaan
    Journal Club
  • Two recent studies have found that both the adaptive immune system and inflammation can drive the selection of cells carrying mutations that facilitate tumour initiation.

    • Sarah Seton-Rogers
    Research Highlight
  • In an effort to bring to our pages some of the vibrant discussion of cancer research that happens during in-person or online journal club meetings, we are now publishing Journal Clubs — an article type in which researchers discuss research papers of their choice with the intention of alerting our readers to articles that have a special significance to them and the field.

    Editorial
  • This issue marks the 20th anniversary of Nature Reviews Cancer. On this milestone birthday we both look back on the past 20 years of cancer research and look forward to the future.

    Editorial
  • In this Journal Club, Brian Rivers highlights a study aimed at enhancing the participation of African American patients in cancer clinical trials.

    • Brian M. Rivers
    Journal Club
  • Using zebrafish and human pluripotent stem cell-derived models of melanoma, Baggiolini, Callahan et al. demonstrate that cells expressing progenitor-like programmes and specific chromatin-modifying enzymes are more readily transformed by BRAFV600E.

    • Sarah Seton-Rogers
    Research Highlight
  • Oren et al. developed a lentiviral barcode library, called Watermelon, to characterize the rare population of cycling persister cancer cells that arise during the course of drug treatment and promote tumour relapse.

    • Anna Dart
    Research Highlight
  • Shiao et al. demonstrate that commensal bacteria and fungi have opposing roles to play in the responses of tumours to radiotherapy.

    • Anna Dart
    Research Highlight
  • Sartori et al. show that disruption of BMP pathway activation is involved in promoting cancer cachexia.

    • Joseph Willson
    In Brief
  • Haas et al. show that acquired resistance to a targeted therapy can result in cross-resistance to immunotherapy through the induction of an immune-evasive microenvironment.

    • Anna Dart
    Research Highlight
  • Significant gaps in access to care have shifted the burden of cervical cancer disease to resource-poor countries in Africa, Asia and Latin America. The recent World Health Organization’s Call to Action to eliminate cervical cancer is a unique opportunity to galvanize change and remove barriers to prevention and care.

    • Karla Alfaro
    • Mauricio Maza
    • Montserrat Soler
    Comment