In cancer research and in the clinic, biomarker assays can be used to not only identify the presence of a tumour, but also to determine its stage, subtype, and ability to respond to therapy. Biomarkers are therefore invaluable tools for cancer detection, diagnosis, patient prognosis and treatment selection. This special Focus issue of Nature Reviews Cancer discusses issues surrounding important genetic, epigenetic and protein biomarkers of cancer, including how these can be used to better understand tumour formation and to develop new therapeutic approaches.


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From the editors

From the editors

doi:10.1038/nrc1805

Nature Reviews Cancer 6, 91


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Research highlights

Biomarkers: Marked aggression

Kristine Novak

doi:10.1038/nrc1806

Nature Reviews Cancer 6, 96

Biomarkers: Taking out the trash

Kristine Novak

doi:10.1038/nrc1807

Nature Reviews Cancer 6, 92

Biomarkers: Different treatment

Patrick Goymer

doi:10.1038/nrc1808

Nature Reviews Cancer 6, 94-95

Trial watch: Predicting treatment outcome | Predicting disease progression

doi:10.1038/nrc1809

Nature Reviews Cancer 6, 95

Reviews

Common markers of proliferation

Michael L. Whitfield, Lacy K. George, Gavin D. Grant and Charles M. Perou

doi:10.1038/nrc1802

Nature Reviews Cancer 6, 99-106

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Stephen B. Baylin and Joyce E. Ohm

doi:10.1038/nrc1799

Nature Reviews Cancer 6, 107-116

Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy

Meyling H. Cheok and William E. Evans

doi:10.1038/nrc1800

Nature Reviews Cancer 6, 117-129

Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics

Cornelia M. Ulrich, Jeannette Bigler and John D. Potter

doi:10.1038/nrc1801

Nature Reviews Cancer 6, 130-140


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Perspectives

Host genetics influence tumour metastasis

Kent Hunter

doi:10.1038/nrc1803

Nature Reviews Cancer 6, 141-146

Mapping normal and cancer cell signalling networks: towards single-cell proteomics

Jonathan M. Irish, Nikesh Kotecha and Garry P. Nolan

doi:10.1038/nrc1804

Nature Reviews Cancer 6, 146-155

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