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The 2023 Nobel prize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their “discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19”.
Image: Springer Nature/The Nobel Foundation/Imagesource
Selected, recent articles from across the Nature Portfolio that document the recent progress in understanding the biology of EV-mediated cell–cell communication and advances in clinical translation of EVs.
One of the fundamental biological processes in life is the cell cycle leading from DNA replication to cell division. While it has been studied for decades and our knowledge has matured, sophisticated experimental approaches have rejuvenated the field. In addition, cell cycle regulators have emerged as cancer therapy targets. This collection showcases ground-breaking cell cycle papers and reviews, ranging from basic discoveries to clinical applications.
Survival for patients with many types of malignant primary brain tumours or with brain metastasis has not improved much in the past 10 years, despite the introduction of some new treatments and despite our improved understanding of the biological bases of brain tumour development and metastasis.
Metastasis, the dissemination of tumour cells from a primary site leading to their colonization at a distant organ, is ultimately what kills most patients with cancer. This Collection from Nature Reviews Cancer presents our most recently published articles on the topic highlighting the advances made in our understanding of the metastatic process.
This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.