Articles in 2014

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  • A screening platform using cell cultures derived from tumour biopsy samples identifies drug combinations that are effective in treating tumour resistance.

    • M. Teresa Villanueva
    Research Highlight
  • This paper finds that levels of histone H3 lysine 79 (H3K79) methylation affect the level of gene expression through the AF10–DOT1L complex, with implications for acute myeloid leukaemia therapy.

    • Gemma K. Alderton
    Research Highlight
  • The identification in 1993 of inherited mutations in the von Hippel–Lindau (VHL) gene in families with VHL disease was a seminal finding. This and subsequent discoveries have given the VHLtumour suppressor gene a central role in our understanding of the mechanisms of cellular oxygen sensing and in the pathobiology of clear-cell renal cell carcinoma.

    • Lucy Gossage
    • Tim Eisen
    • Eamonn R. Maher
    Timeline
  • Hyperactivation of phosphatidylinositol 3-kinase (PI3K) signalling cascades is one of the most common events in human cancers. This Review discusses recent advances in our knowledge of the roles of distinct PI3K isoforms in normal and oncogenic signalling, and the current state and future potential of targeting this pathway in the clinic.

    • Lauren M. Thorpe
    • Haluk Yuzugullu
    • Jean J. Zhao
    Review Article
  • Elsa Flores and colleagues have found that a pancreatic hormone, amylin, induces regression ofTrp53-null tumours.

    • Nicola McCarthy
    Research Highlight
  • Seven new studies advance our understanding of immune checkpoint blockade and highlight an approach for developing personalized cancer vaccines.

    • Yvonne Bordon
    Research Highlight
  • Data from three recent papers suggest that alterations of super-enhancers in cancer cells can promote oncogene expression and therapeutic resistance in some cases. Proteins that promote transcription from super-enhancers might be viable therapeutic targets.

    • Sarah Seton-Rogers
    Research Highlight
  • Complementing government and industry funding, philanthropies have made distinct contributions to altering the trajectory of cancer research. This Science and Society article aims to investigate the changing role of philanthropy in fostering cancer research, with emphasis on the work of non-profit institutions.

    • Yonina R. Murciano-Goroff
    Science and Society