Tools of the Trade

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  • In this Tools of the Trade article, Luigi Ombrato describes the development of Cherry-niche, a cell labelling system, which enables the unbiased identification of cancer cell-neighbouring cells.

    • Luigi Ombrato
    Tools of the Trade
  • In this Tools of the Trade article, Daniela S. Thommen describes the development and use of a patient-derived tumour fragment (PDTF) platform wherein surgically resected tumour lesions are cultured ex vivo, which enables patients’ responses to immunotherapy to be more faithfully modelled.

    • Daniela S. Thommen
    Tools of the Trade
  • In this Tools of the Trade article, Anne C. Rios describes the development of multispectral large-scale single-cell resolution three-dimensional (mLSR-3D) imaging and the analytical pipeline, segmentation analysis by parallelization of 3D datasets (STAPL-3D), which enables the extraction of hundreds of molecular, spatial and volumetric features from millions of cells imaged in 3D, revealing details of the structural organization of human tumours.

    • Anne C. Rios
    Tools of the Trade
  • In this Tools of the Trade article, Amir Giladi describes the development and use of PIC-seq, which enables the direct enrichment and analysis of conjugates of physically interacting cells in the tumour microenvironment.

    • Amir Giladi
    Tools of the Trade
  • In this Tools of the Trade article, Yaara Oren describes the development and use of the Watermelon system to simultaneously track the lineage, transcriptional profile and proliferative state of each cancer cell in a population, which enables the characterization of rare cycling persister cells.

    • Yaara Oren
    Tools of the Trade
  • In this Tools of the Trade article, Ana Luísa Correia describes the development and use of a tracker of dormant disseminated tumour cells to investigate the distribution and dynamics of dormant reservoirs within and across distant sites.

    • Ana Luísa Correia
    Tools of the Trade
  • In this Tools of the Trade article, Alejandro E. Mayorca-Guiliani describes the development and use of in situ decellularization, which allows native extracellular matrix to be preserved to address both tumour deconstruction and reassembly.

    • Alejandro E. Mayorca-Guiliani
    Tools of the Trade
  • In this Tools of the Trade article, Eunhee Yi describes the development and use of a method called ecTag, which allows imaging and tracking of extrachromosomal DNA in live cancer cells.

    • Eunhee Yi
    Tools of the Trade