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When p53 was first discovered, it received relatively little attention from cancer researchers. The road leading to p53's rise to fame, and the recognition ofTP53as the most frequently altered gene in human cancer, has been long and winding. This Timeline examines the rich history of this pivotal tumour suppressor.
Understanding the activities of p53 in tumour suppression and in other processes has been substantially aided by the use of mouse models. How have these models evolved and what have they taught us about p53 and tumour suppression?
Ever since its discovery, apoptosis has been inextricably linked with cancer. This Timeline article seeks to provide insights into the key discoveries in the field and therapeutic applications based on apoptotic strategies.
Cancer prevention is a global priority, but history indicates that the journey towards achieving this goal is fraught with difficulties. What can we learn from the past that is applicable to the reality of successful cancer prevention?
Tumour necrosis factor (TNF) was initially isolated as a factor that induced necrosis of cancer cells. However, it has become clear that TNF can also promote cancer. This Timeline examines the long history of TNF in cancer biology, asking whether it is a target, a therapeutic or both.
