In Brief

Luo et al. uncover strong associations between the tumour microbiome and race, a finding that further emphasises the need for race diversity in cancer studies.

Wright et al. reveal how methotrexate binds to the human reduced folate carrier and outline key features that will aid the rational design of targeted antifolate therapeutics.

Kaushik Tiwari et al. have developed a strategy to directly target amplified genes in cancer using triplex-forming oligonucleotides, which selectively induce DNA damage and apoptosis in cancer cells with copy number gains.

Guo et al. have developed a novel strategy, which involves coating tumour cells with silica, to enable personalized cancer vaccines to overcome the immunosuppressive effects of the tumour microenvironment.

Schneider et al. show that peripheral serotonin augments colorectal and pancreatic tumour growth in mice by increasing PDL1 expression on cancer cells, and in turn inhibiting the accumulation of functional CD8⁺ T cells within tumours.

Xu et al. have uncovered a novel and unexpected role for the ERα as a non-canonical RNA-binding protein, which functions to maintain breast cancer cell survival and tamoxifen resistance.

Berta et al. show that epigenetic remodelling promotes the development of uterine fibroids.

Sartori et al. show that disruption of BMP pathway activation is involved in promoting cancer cachexia.

Martirosian et al. show that a metabolic mechanism used by neurons and astrocytes during periods of nutrient deprivation and stress may have a role in leptomeningeal dissemination of medulloblastoma.

Andrews et al. provide evidence that immune-related adverse events following cancer immunotherapy may be linked to the patient’s gut microbiota.

Griffin, Wu, Iracheta-Vellve et al. identified SETDB1 as an immunosuppressive epigenetic modulator in cancer.

Wang et al. showed that monoamine-oxidase A, a regulator of neuronal activity, functions as a negative feedback regulator of T cell activity in tumours.

Bach et al. find that loss of the tumour suppressor BRCA1 may drive the development of triple negative breast cancer through inducing aberrant alveolar differentiation of luminal progenitor cells.

Ueda et al. report that overexpression of MDMX in pre-leukaemic stem cells provides these cells with a competitive advantage and promotes the progression of various pre-leukaemic conditions to acute myeloid leukaemia in several mouse models.