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  • Comment |

    Research funders are uniquely placed to develop and promote collaborations between multiple partners, including industry, in a positive and ethical way. This Comment calls for funders to take action to ensure that discoveries progress from the lab to patients with cancer.

    • George Tzircotis
    • , Tony Hickson
    •  & Iain Foulkes
  • Comment |

    There is evidence of a mounting mental health crisis among researchers, which may be exacerbated by the COVID-19 pandemic. This Comment article discusses what cancer researchers and institutions can do to promote good mental health and wellbeing within their research communities.

    • Jane Creaton
  • Comment |

    The COVID-19 pandemic has broadly impacted biomedical research and health care. Here we discuss current challenges for the cancer research community as they apply to early career investigators (ECIs). We propose a series of collaborative initiatives aimed to sustain ECIs and preserve and accelerate the ability to innovate with long-lasting impact.

    • Ross L. Levine
    •  & W. Kimryn Rathmell
  • Comment |

    In conflict-affected areas, people experience significant challenges in health-care delivery, and this situation is even more extreme for patients with cancer. Until now, research on access to cancer treatment and care as well as cancer disparities in war-torn and post-war regions has been limited. Therefore, we advocate coordinated, global action to address this issue and implement evidence-based solutions.

    • Dina Mired
    • , Sonali Johnson
    •  & Gevorg Tamamyan
  • Comment |

    In this Comment, the author, a cancer researcher and breast cancer survivor, discusses her experience as a patient with cancer and how it influenced her approach to research.

    • Cynthia A. Zahnow
  • Comment |

    This Comment article argues that the future successes of rare cancer research will require alternative approaches for diagnosing, researching and conducting clinical trials, which will ultimately benefit patients with all types of cancer.

    • Holly E. Barker
    •  & Clare L. Scott
  • Comment |

    The use of social media for the dissemination of published and unpublished scientific findings has exploded over the past few years. In this Comment article, Soragni and Maitra explain some of the ways in which Twitter can be used by academics to promote their science.

    • Alice Soragni
    •  & Anirban Maitra
  • Comment |

    In an effort to prevent bullying and harassment in the research sector, funding bodies have introduced policies to promote a positive research culture. Here, Sue Russell and Iain Foulkes comment on what this means for researchers.

    • Sue Russell
    •  & Iain Foulkes
  • Comment |

    Cancer brings an increasing health and economic burden worldwide, and the greatest impact is had on the most vulnerable populations. In this Comment, Christopher Wild discusses the need for investment to ensure long-term cancer prevention strategies.

    • Christopher P. Wild
  • Comment |

    Comprehensive genomic characterization of patient tumours has the potential to advance therapies and inform basic cancer research. In this Comment, David B. Solit and colleagues provide their personal perspective on the implementation of an enterprise-wide, prospective clinical sequencing strategy and make a call for a universal approach to next-generation sequencing-based tumour profiling.

    • Michael L. Cheng
    • , Michael F. Berger
    • , David M. Hyman
    •  & David B. Solit
  • Comment |

    Most of our current knowledge of melanoma is derived from the study of patients from populations of European descent, for whom public health, sun protection initiatives and screening measures have appreciably decreased disease mortality. Notably, some melanoma subtypes that most commonly develop in other populations are not associated with exposure to ultraviolet (UV) light, suggesting a different disease aetiology. Further study of these subtypes is necessary to understand their risk factors and genomic architecture, and to tailor therapies and public health campaigns to benefit patients of all ethnic groups.

    • Raul Ossio
    • , Rodrigo Roldán-Marín
    • , Héctor Martínez-Said
    • , David J. Adams
    •  & Carla Daniela Robles-Espinoza
  • Comment |

    Hosteet al. discuss whether allergic immune responses, which have been observed to be protective against some types of cancer, can be activated to target cancer, and what the mechanism of antitumour allergic responses might be.

    • Esther Hoste
    • , Sara Cipolat
    •  & Fiona M. Watt
  • Comment |

    This Comment article argues that we should more comprehensively study the biology of benign tumours, as this might provide crucial insights into our understanding of cancer biology and metastasis.

    • Adrian Marino-Enriquez
    •  & Christopher D. M. Fletcher
  • Comment |

    The incidence of cancer in the small intestine is considerably lower than the incidence of cancer in the large intestine. Why might this be? This article suggests that the microbiota might be part of the explanation for this difference.

    • Fergus Shanahan
    •  & Paul W. O'Toole
  • Comment |

    Metaplastic breast carcinoma (MBC) accounts for 0.2–5% of invasive breast cancers. The majority of MBCs have a triple-negative phenotype, are highly heterogeneous and respond poorly to chemotherapy. Understanding their divergent differentiation and identifying the cell of origin might provide some much-needed insight into this disease.

    • Britta Weigelt
    • , Carey Eberle
    • , Catherine F. Cowell
    • , Charlotte K. Y. Ng
    •  & Jorge S. Reis-Filho
  • Comment |

    NUT midline carcinoma, a squamous cell carcinoma, is one of the most aggressive human cancers, and there is a desperate need for effective therapies for patients with this disease.

    • Christopher French
  • Comment |

    Despite a ban on the use of plants of theAristolochiagenus in herbal medicine, as they contain known carcinogens, urothelial carcinoma attributable to the use of this plant seems to be more common than previously thought.

    • Magali Olivier
    • , Monica Hollstein
    • , Heinz Hans Schmeiser
    • , Kurt Straif
    •  & Christopher P. Wild
  • Comment |

    The seminal article by Douglas Hanahan and Robert Weinberg on the hallmarks of cancer is 10 years old this year and its contribution to how we see cancer has been substantial. But, in embracing this view, have we lost sight of what makes cancer cancer?

    • Yuri Lazebnik