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  • In this Review, Zhang and colleagues provide an overview of the molecular characteristics of paediatric cancer and highlight how these malignancies arise from developmental aberrations resulting in paediatric-specific cancer genomes that influence both the initiation and progression of cancer. Additionally, they discuss genetic vulnerabilities within these cancer genomes that present opportunities for therapeutic interventions.

    • Xiaolong Chen
    • Wentao Yang
    • Jinghui Zhang
    Review Article
  • Dias et al. have shown that intentional further activation of oncogenic signalling rather than its inhibition represents an alternative strategy leading to colorectal cancer cell death with tumour suppressive acquired resistance.

    • Anna Dart
    Research Highlight
  • In this Tools of the Trade article, Zuzana Tatarova describes the development of MIMA, an integrated analytical platform providing the quantitative information on tumour microenvironment drug responses required for effective treatment design.

    • Zuzana Tatarova
    Tools of the Trade
  • In this Tools of the Trade article, Daniel Kirschenbaum describes the development of Zman-seq and its utility for capturing dynamic changes in cellular state within single-cell RNA sequencing data.

    • Daniel Kirschenbaum
    Tools of the Trade
  • Generalist medical artificial intelligence (GMAI) models are gaining momentum in their applications for cancer treatment. In this Comment, Gilbert and Kather advocate for novel regulation of GMAI approaches to ensure patient safety and adequate physician support.

    • Stephen Gilbert
    • Jakob Nikolas Kather
    Comment
  • In this Review, Cichowski and colleagues provide an overview of combinatorial strategies designed to treat RAS-driven cancers that are based on four concepts that include vertical pathway inhibition, co-targeting RAS and adaptive survival pathways, co-targeting downstream or converging pathways and capitalizing on other cancer-associated vulnerabilities.

    • Naiara Perurena
    • Lisa Situ
    • Karen Cichowski
    Review Article
  • In a recent study published in Nature, Goto et al. explore mechanisms of immune evasion in early colorectal cancers and adenomas and identify SOX17 to be crucial for immune escape through suppression of interferon-γ signalling.

    • Daniela Senft
    Research Highlight
  • In this recent study, He et al. establish that chronic stress promotes metastasis through stress-induced formation of neutrophil extracellular traps (NETs).

    • Gabrielle Brewer
    Research Highlight
  • Tumour-associated lymphatic growth and remodelling were once viewed as a passive means by which cancer cells could regionally spread to lymph nodes. However, recent data point to an active and contrasting role for lymphatic vessels and their transport in antitumour immune surveillance. In this Review, Karakousi et al. provide a working framework to define this role for the lymphatic system in tumour progression and present avenues for its therapeutic manipulation to improve cancer immunotherapy.

    • Triantafyllia Karakousi
    • Tenny Mudianto
    • Amanda W. Lund
    Review Article
  • Sánchez-Guixé et al. investigated the possible routes to second malignancies in survivors of paediatric cancer by studying four such clinical cases.

    • Anna Dart
    Research Highlight
  • In this Tools of the Trade article, Kaile Wang describes the development and use of Arc-well, a high-throughput single-cell DNA sequencing method tailored to analyse archival formalin-fixed paraffin-embedded (FFPE) materials.

    • Kaile Wang
    Tools of the Trade
  • Metastatic cancer represents the main cause of death in patients with cancer, but metastasis research is hindered by the limited availability of metastatic samples. In this Comment, Desmedt and Carey highlight the opportunities and challenges of post-mortem tissue donation programmes, which represent a complementary and attractive solution to overcome many of the hurdles in metastasis research.

    • Christine Desmedt
    • Lisa A Carey
    Comment
  • Sex differences impact various non-reproductive organ cancers, often leading to higher cancer incidence and poorer outcomes in male individuals. In this Perspective article, Xiao, Lee et al. outline the biological factors contributing to sex bias in immuno-oncology, emphasizing the need for future research to offer a fuller understanding of sex disparities in cancer.

    • Tong Xiao
    • Juyeun Lee
    • Zihai Li
    Perspective
  • In this World View, H. Michael Shepard describes his personal story behind the discovery of trastuzumab, 25 years since its FDA approval for HER2-overexpressing breast cancers.

    • H. Michael Shepard
    World View
  • Fu et al. provide data indicating a pathogenic role for Streptococcus anginosus in gastric cancer.

    • Anna Dart
    Research Highlight
  • Recently published in Nature, Fan et al. demonstrate that accumulation of advanced glycation end-products in the extracellular matrix of the liver increases viscoelasticity to promote hepatocellular carcinoma growth, independent of stiffness.

    • Gabrielle Brewer
    Research Highlight
  • Two independent studies published in Nature implicate distal cholesterol biosynthesis in the regulation of ferroptosis and show that 7-dehydrocholesterol (7-DHC) is an endogenous, anti-ferroptotic metabolite.

    • Daniela Senft
    Research Highlight
  • This Review provides an overview of the complexity and significance of protein lipidation in cancer, outlines how targeting protein lipidation pathways offer promising avenues for developing cancer treatments, and discusses the current state of drugs targeting these pathways.

    • Edward W. Tate
    • Lior Soday
    • Hening Lin
    Review Article