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  • In two studies published concurrently, Pal et al. and Shi et al. reveal that certain gliomas rely on the de novo synthesis of pyrimidines. These studies go on to demonstrate the effectiveness of brain-penetrant inhibitors of de novo pyrimidine synthesis in preclinical models of glioma.

    • Joseph Willson
    Research Highlight
  • Clinical trials of immunotherapies have so far failed to demonstrate efficacy in high-grade serous ovarian cancers. Here, Kandalaft et al. classify high-grade serous ovarian cancers into distinct immunophenotypes that might account for these failures and could also provide a rational basis for tailored immunotherapy in the future.

    • Lana E. Kandalaft
    • Denarda Dangaj Laniti
    • George Coukos
    Review Article
  • Chen et al. have developed a preclinical platform that enables the reprogramming of locoregional macrophages and microglia in situ with CD133-directed chimeric antigen receptors, which leads to the phagocytosis and removal of residual glioma stem cells after tumour debulking.

    • Anna Dart
    Research Highlight
  • Seki et al. show that exposure to cold suppresses tumour growth in mice through increasing glucose uptake and thermogenesis in brown adipose tissue.

    • Joseph Willson
    Research Highlight
  • The increasing size of cancer datasets requires new ways of thinking for analysing and integrating these data. In this Review, Jiang et al. discuss considerations and strategies for wielding ‘big data’ ― large, information-rich datasets ― in basic research and for translational applications such as identifying biomarkers, informing clinical trials and developing new assays and treatments.

    • Peng Jiang
    • Sanju Sinha
    • Eytan Ruppin
    Review Article
  • In this Tools of the Trade article, Anne C. Rios describes the development of multispectral large-scale single-cell resolution three-dimensional (mLSR-3D) imaging and the analytical pipeline, segmentation analysis by parallelization of 3D datasets (STAPL-3D), which enables the extraction of hundreds of molecular, spatial and volumetric features from millions of cells imaged in 3D, revealing details of the structural organization of human tumours.

    • Anne C. Rios
    Tools of the Trade
  • In this Comment article, Bhangu and Caduff describe how the social science of medical anthropology uses qualitative methods to better understand how people in different parts of the world perceive and experience illness, and how this field of study emphasizes research approaches that humanize and add richness to our understanding of cancer in complex settings.

    • Shagufta Bhangu
    • Carlo Caduff
    Comment
  • Venkataramani et al. used longitudinal intravital two-photon imaging to track migrating glioblastoma cells in vivo, and identified a seemingly unconnected cell subpopulation that was responsible for colonization of the brain by mimicking neuronal mechanisms of movement.

    • Anna Dart
    Research Highlight
  • Malignant cells show uninhibited proliferation and cellular plasticity, features also reminiscent of embryogenesis. In this Perspective, Sharma and colleagues present their oncofetal ecosystem concept, discuss evidence of oncofetal reprogramming in malignant and non-malignant cells, and debate the therapeutic relevance of these findings.

    • Ankur Sharma
    • Camille Blériot
    • Florent Ginhoux
    Perspective
  • This Review describes how advances in lentiviral-based cellular barcoding techniques, including both genetic and optical barcoding, have enabled the spatiotemporal fate of individual cancer cells and their progeny to be tracked, providing valuable information for biological discovery and possible clinical translation.

    • Antonin Serrano
    • Jean Berthelet
    • Delphine Merino
    Review Article
  • In this Viewpoint article, we asked four scientists working in the field of cancer nanomedicine to provide their opinions on how we can truly fulfil the great promise of nanotechnologies for the detection, diagnosis and treatment of patients with cancer.

    • Sangeeta N. Bhatia
    • Xiaoyuan Chen
    • Twan Lammers
    Viewpoint
  • Using single-cell transcriptomic data, Joanito et al. reveal that colorectal cancers can be defined by the presence of one of two major intrinsic epithelial subtypes, and present a refined molecular classification system for these cancers.

    • Joseph Willson
    Research Highlight
  • This review gives an overview of natural killer (NK) cell-based immunotherapies. The authors describe the various engineering strategies used to increase NK cell cytotoxicity and persistence, as well as the current challenges and opportunities for the future design of next-generation NK cell therapies.

    • Tamara J. Laskowski
    • Alexander Biederstädt
    • Katayoun Rezvani
    Review Article
  • Finding sex differences in the response of patients with melanoma to BRAF/MEK-targeted therapy, Vellano et al. show that this effect is mediated by androgen receptor expression and demonstrate that androgen receptor blockers can enhance treatment response.

    • Joseph Willson
    Research Highlight
  • Diamantopoulou et al. have found that in both mouse models and patients with breast cancer, the timing of spontaneous circulating tumour cell production coincides with sleep.

    • Anna Dart
    Research Highlight
  • Environmental exposure to aristolochic acid-containing plant material and its use in traditional medicines have been linked to a wide range of cancers. In this Review, Das et al. describe the evidence for aristolochic acid as a potent carcinogen and explore the impact of public health measures on preventing aristolochic acid-linked cancers and nephropathy, with a call to action for the implementation of further preventative measures.

    • Samrat Das
    • Shefali Thakur
    • Jiri Zavadil
    Review Article
  • Zhang et al. demonstrate that the adenosine deaminase ADAR1 prevents responsiveness to immune checkpoint blockade (ICB) through acting on cellular Z-nucleic acids, and show inducing Z-nucleic acid formation can induce tumour sensitivity to ICB.

    • Joseph Willson
    Research Highlight