Browse Articles

Filter By:

  • Genes encoding DNA damage response factors are frequently mutated in cancer, causing genomic instability and presenting opportunities for therapeutic intervention. This Review discusses state-of-the-art strategies for DNA damage response inactivation using small-molecule inhibitors.

    • Florian J. Groelly
    • Matthew Fawkes
    • Madalena Tarsounas
    Review Article
  • Two recent studies have demonstrated how senescent cancer cells alter their cell surface proteome to induce anti-tumour immune responses, highlighting the potential therapeutic role of inducing senescence to improve anti-tumour immunity.

    • Gabrielle Brewer
    Research Highlight
  • Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and its incidence continues to rise, mostly owing to an increase in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. In this Review, the authors describe HPV-positive and HPV-negative HNSCC tumour microenvironments and discuss current and novel treatment modalities.

    • Ayana T. Ruffin
    • Housaiyin Li
    • Tullia C. Bruno
    Review Article
  • In this study, Cao et al. identified previously undiscovered metabolites produced by human gut microbes that cause DNA damage, and analysed their implication for colorectal cancer development.

    • Daniela Senft
    Research Highlight
  • Schmitt et al. describe an adaptive mechanism employed by colorectal cancers to handle pro-apoptotic chemotherapeutic insults, which could represent a targetable vulnerability with combination therapy.

    • Anna Dart
    Research Highlight
  • Pancreatic ductal adenocarcinomas are characterized by a robust stromal reaction. This Review discusses how the evolution of the epithelium in pancreatic cancers is coordinated with a programme of stromal progression; this comprehensive picture of tumour development might, in turn, point to new therapeutic vulnerabilities.

    • Sunil R. Hingorani
    Review Article
  • In this Perspective, Wahida et al. consider six riddles in precision oncology that must be solved to achieve better clinical responses to molecular targeted therapies.

    • Adam Wahida
    • Lars Buschhorn
    • Razelle Kurzrock
    Perspective
  • This Review covers recent advances in intravital imaging of mammalian models of cancer and describes how intravital imaging can help to understand the role of the tumour microenvironment in cancer progression and metastasis, and to develop novel treatments and therapies.

    • David Entenberg
    • Maja H. Oktay
    • John S. Condeelis
    Review Article
  • Notarangelo et al. reveal that the oncometabolite d-2-hydroxyglutarate, which is released in high quantities by tumour cells, is taken up by CD8+ T cells in the tumour microenvironment and blocks their proliferation and cytotoxicity by inhibition of lactate dehydrogenase and metabolic reprogramming.

    • Joseph Willson
    Research Highlight
  • Social media has revolutionized health-care communication across medicine, particularly in the field of oncology. In this Comment, Manochakian and Dizon highlight the role of social media in promoting patient-driven cancer research to benefit all.

    • Rami Manochakian
    • Don S. Dizon
    Comment
  • In two studies published concurrently, Dohlman et al. and Narunsky-Haziza et al. have found strong correlative links between the prevalence of fungal DNA and cancer.

    • Gabrielle Brewer
    Research Highlight
  • The activation of DNA damage tolerance (DDT) pathways as part of the replication stress response to DNA damage is key for maintaining genome integrity and, as a result, these pathways are closely linked to tumorigenesis. In this Review, Cybulla and Vindigni discuss the many connections between DDT, replication stress and cancer, detail opportunities for clinical biomarker development, and outline therapeutic strategies for targeting these pathways.

    • Emily Cybulla
    • Alessandro Vindigni
    Review Article
  • Karras et al. map cell state diversity in melanoma and identify a cellular hierarchy that is regulated by microenvironmental cues.

    • Daniela Senft
    Research Highlight
  • Three-dimensional bioprinted cancer models could revolutionize understanding and treatment of cancer. Neufeld, Yeini and Pozzi discuss how such models can reveal novel biomarkers and drug targets, illuminate mechanisms of tumorigenesis and interactions between tumour, stromal and immune cells, and advance personalized cancer therapy.

    • Lena Neufeld
    • Eilam Yeini
    • Ronit Satchi-Fainaro
    Review Article
  • ‘Ductal carcinoma in situ’ (DCIS) describes abnormal cells in the milk ducts. DCIS is often non-invasive, although a small proportion of cases leave the ducts and progress to invasive breast cancer. This Review discusses the existing data for distinguishing progressive and non-progressive DCIS, with a focus on informing current disease management strategies.

    • Anna K. Casasent
    • Mathilde M. Almekinders
    • Marja van Oirsouw
    Review Article
  • The gut microbiota has been shown to regulate responses to various cancer therapies, and the microbial species involved and their underlying mechanisms have begun to be unravelled. In this Perspective, Fernandes and colleagues present this evidence and then outline how it could be used to develop microbiota-based therapies for patients with cancer.

    • Miriam R. Fernandes
    • Poonam Aggarwal
    • Giorgio Trinchieri
    Perspective
  • In this Tools of the Trade article, Venkataramani describes the development of in vivo imaging workflows that allow the acquisition of imaging data with improved signal-to-noise matched to single-cell RNA-sequencing data.

    • Varun Venkataramani
    Tools of the Trade
  • Kalkavan et al. find sublethal cytochrome c release leads to a caspase-independent, ATF4-dependent drug-tolerant persister phenotype.

    • Gabrielle Brewer
    Research Highlight
  • Using single-cell RNA-seq and functional analysis in prostate cancer organoids and mouse models, Chan et al. identify inflammatory JAK–STAT signalling to drive the transition of adenocarcinomas to neuroendocrine prostate cancer.

    • Daniela Senft
    Research Highlight
  • Luo et al. uncover strong associations between the tumour microbiome and race, a finding that further emphasises the need for race diversity in cancer studies.

    • Joseph Willson
    In Brief