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  • In this Perspective, the authors suggest that different tumour microenvironments have ‘archetypal’ qualities across all cancers — characteristic and repeating collections of cells and gene-expression profiles at the level of the bulk tumour. They propose the existence of 12 dominant immune archetypes.

    • Alexis J. Combes
    • Bushra Samad
    • Matthew F. Krummel
  • In this Tool of the Trade article, Eva Freckmann describes the development of Traject3d, a workflow that enables the detection of heterogeneous phenotypes in 3D culture by analysing label-free multi-day time-lapse imaging.

    • Eva C. Freckmann
    Tools of the Trade
  • In this Review, Schwenck et al. discuss how PET imaging of cancer has advanced through its combination with CT and MRI and the development of an array of imaging probes, and how these innovations now need to be fully integrated into the clinic to improve cancer diagnostics and guide therapy.

    • Johannes Schwenck
    • Dominik Sonanini
    • Bernd J. Pichler
    Review Article
  • In this study, Insco et al. find patient-specific CDK13 mutations to impede RNA surveillance, leading to the accumulation and translation of prematurely terminated RNAs that drive malignancy in melanoma models.

    • Gabrielle Brewer
    Research Highlight
  • In this Review, Banushi et al. discuss how endocytotic pathways impact many cancer processes including nutrient scavenging, metastasis and therapeutic drug delivery, and how knowledge of these pathways can be used to improve cancer therapy in the clinic.

    • Blerida Banushi
    • Shannon R. Joseph
    • Fiona Simpson
    Review Article
  • Sloan and colleagues demonstrate that anthracycline chemotherapy drives metastatic progression by stimulating a cancer cell-mediated increase in nerve fibre activity in the tumour microenvironment, which can be reversed by the use of β-blockers.

    • Daniela Senft
    Research Highlight
  • In a recent study on castration-resistant prostate cancer, Cui et al. uncover a role for cancer-associated fibroblasts (CAFs) in inducing androgen synthesis in prostate cancer cells.

    • Gabrielle Brewer
    Research Highlight
  • Eukaryotic initiation factor 4F (eIF4F) controls the translation of a subset of transcripts that include those encoding oncogenic proteins. In this Perspective article, Bartish et al. discuss the implications of targeting eIF4F on immune and stromal cells in the tumour microenvironment. In addition to discussing data from cancer models, the authors incorporate extensive data from non-cancer contexts to identify potential desirable or unwanted effects of eIF4F inhibition in these cells.

    • Margarita Bartish
    • Madelyn J. Abraham
    • Sonia V. del Rincón
  • Although metastasis is the leading cause of cancer-related deaths, our understanding of the process is limited. In this Review, Hebert et al. discuss the key features of various models of metastasis, highlighting their advantages and disadvantages for further dissecting mechanisms of metastasis and developing metastasis-targeted therapies.

    • Jess D. Hebert
    • Joel W. Neal
    • Monte M. Winslow
    Review Article
  • In this Tools of the Trade article, Zhenqin Wu describes the development and use of SPACE-GM, a graph deep learning tool that enables the detection of spatial cellular structures predictive of outcomes of patients with cancer.

    • Zhenqin Wu
    Tools of the Trade
  • Blanpain and colleagues provide evidence that the small RHO GTPase, RHOJ, mediates resistance to chemotherapy in tumour cells that have undergone epithelial-to-mesenchymal transition by enabling these cells to tolerate replicative stress and promote DNA damage repair.

    • Anna Dart
    Research Highlight
  • This Review outlines how the developmental pathways that are involved in melanocyte development and skin pigmentation are highjacked by melanoma cells to drive melanomagenesis, progression and therapy resistance.

    • Patricia P. Centeno
    • Valeria Pavet
    • Richard Marais
    Review Article
  • In this Tool of the Trade article, Tatiana Flisikowska describes the development and use of humanized minipigs that allow the preclinical safety testing of human therapeutic antibodies.

    • Tatiana Flisikowska
    Tools of the Trade
  • In this Tool of the Trade article, Mateusz Legut describes the development and use of OverCITE-seq, a new single-cell multiomics approach enabling the high-throughput quantification of the transcriptome and surface antigens in cells expressing a library of open reading frames.

    • Mateusz Legut
    Tools of the Trade
  • Knowledge of the native T cell landscape and how it evolves under immunotherapeutic pressure will enable us to improve upon current clinical responses to immune-based interventions. In this Review, Oliveira and Wu outline how recent multidimensional single-cell studies have brought us a step closer to this goal by linking intratumoural phenotypes with the antigen specificity of T cells.

    • Giacomo Oliveira
    • Catherine J. Wu
    Review Article