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  • In this Perspective, Wahida et al. consider six riddles in precision oncology that must be solved to achieve better clinical responses to molecular targeted therapies.

    • Adam Wahida
    • Lars Buschhorn
    • Razelle Kurzrock
    Perspective
  • This Review covers recent advances in intravital imaging of mammalian models of cancer and describes how intravital imaging can help to understand the role of the tumour microenvironment in cancer progression and metastasis, and to develop novel treatments and therapies.

    • David Entenberg
    • Maja H. Oktay
    • John S. Condeelis
    Review Article
  • Notarangelo et al. reveal that the oncometabolite d-2-hydroxyglutarate, which is released in high quantities by tumour cells, is taken up by CD8+ T cells in the tumour microenvironment and blocks their proliferation and cytotoxicity by inhibition of lactate dehydrogenase and metabolic reprogramming.

    • Joseph Willson
    Research Highlight
  • Social media has revolutionized health-care communication across medicine, particularly in the field of oncology. In this Comment, Manochakian and Dizon highlight the role of social media in promoting patient-driven cancer research to benefit all.

    • Rami Manochakian
    • Don S. Dizon
    Comment
  • In two studies published concurrently, Dohlman et al. and Narunsky-Haziza et al. have found strong correlative links between the prevalence of fungal DNA and cancer.

    • Gabrielle Brewer
    Research Highlight
  • The activation of DNA damage tolerance (DDT) pathways as part of the replication stress response to DNA damage is key for maintaining genome integrity and, as a result, these pathways are closely linked to tumorigenesis. In this Review, Cybulla and Vindigni discuss the many connections between DDT, replication stress and cancer, detail opportunities for clinical biomarker development, and outline therapeutic strategies for targeting these pathways.

    • Emily Cybulla
    • Alessandro Vindigni
    Review Article
  • Karras et al. map cell state diversity in melanoma and identify a cellular hierarchy that is regulated by microenvironmental cues.

    • Daniela Senft
    Research Highlight
  • Three-dimensional bioprinted cancer models could revolutionize understanding and treatment of cancer. Neufeld, Yeini and Pozzi discuss how such models can reveal novel biomarkers and drug targets, illuminate mechanisms of tumorigenesis and interactions between tumour, stromal and immune cells, and advance personalized cancer therapy.

    • Lena Neufeld
    • Eilam Yeini
    • Ronit Satchi-Fainaro
    Review Article
  • ‘Ductal carcinoma in situ’ (DCIS) describes abnormal cells in the milk ducts. DCIS is often non-invasive, although a small proportion of cases leave the ducts and progress to invasive breast cancer. This Review discusses the existing data for distinguishing progressive and non-progressive DCIS, with a focus on informing current disease management strategies.

    • Anna K. Casasent
    • Mathilde M. Almekinders
    • Marja van Oirsouw
    Review Article
  • The gut microbiota has been shown to regulate responses to various cancer therapies, and the microbial species involved and their underlying mechanisms have begun to be unravelled. In this Perspective, Fernandes and colleagues present this evidence and then outline how it could be used to develop microbiota-based therapies for patients with cancer.

    • Miriam R. Fernandes
    • Poonam Aggarwal
    • Giorgio Trinchieri
    Perspective
  • In this Tools of the Trade article, Venkataramani describes the development of in vivo imaging workflows that allow the acquisition of imaging data with improved signal-to-noise matched to single-cell RNA-sequencing data.

    • Varun Venkataramani
    Tools of the Trade
  • Kalkavan et al. find sublethal cytochrome c release leads to a caspase-independent, ATF4-dependent drug-tolerant persister phenotype.

    • Gabrielle Brewer
    Research Highlight
  • Using single-cell RNA-seq and functional analysis in prostate cancer organoids and mouse models, Chan et al. identify inflammatory JAK–STAT signalling to drive the transition of adenocarcinomas to neuroendocrine prostate cancer.

    • Daniela Senft
    Research Highlight
  • Luo et al. uncover strong associations between the tumour microbiome and race, a finding that further emphasises the need for race diversity in cancer studies.

    • Joseph Willson
    In Brief
  • Wright et al. reveal how methotrexate binds to the human reduced folate carrier and outline key features that will aid the rational design of targeted antifolate therapeutics.

    • Joseph Willson
    In Brief
  • In this Tools of the Trade article, Luigi Ombrato describes the development of Cherry-niche, a cell labelling system, which enables the unbiased identification of cancer cell-neighbouring cells.

    • Luigi Ombrato
    Tools of the Trade
  • Ma et al. demonstrate that platelets suppress liver tumour growth in the context of non-alcoholic fatty liver disease through T cell-dependent antitumour immunity.

    • Daniela Senft
    Research Highlight
  • Xu, Yan et al. show that the hypothalamic–pituitary unit produces α-melanocyte-stimulating hormone in tumour-bearing mice, to promote myelopoiesis and immunosuppression.

    • Gabrielle Brewer
    Research Highlight
  • In this Tools of the Trade article, Daniela S. Thommen describes the development and use of a patient-derived tumour fragment (PDTF) platform wherein surgically resected tumour lesions are cultured ex vivo, which enables patients’ responses to immunotherapy to be more faithfully modelled.

    • Daniela S. Thommen
    Tools of the Trade