• birthday balloons that look like cancer cells making the number 20

    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

  • two people representing an early-career researcher and their mentor

    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • "crab" symbol formed from individual cancer cells

    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

  • group of women

    This series of articles explores recent advances in our understanding of tumour metabolism and growth in the context of systemic regulation, diet and metabolic disease.


  • Two recent studies have demonstrated how senescent cancer cells alter their cell surface proteome to induce anti-tumour immune responses, highlighting the potential therapeutic role of inducing senescence to improve anti-tumour immunity.

    • Gabrielle Brewer
    Research Highlight
  • In this study, Cao et al. identified previously undiscovered metabolites produced by human gut microbes that cause DNA damage, and analysed their implication for colorectal cancer development.

    • Daniela Senft
    Research Highlight
  • Schmitt et al. describe an adaptive mechanism employed by colorectal cancers to handle pro-apoptotic chemotherapeutic insults, which could represent a targetable vulnerability with combination therapy.

    • Anna Dart
    Research Highlight
  • Notarangelo et al. reveal that the oncometabolite d-2-hydroxyglutarate, which is released in high quantities by tumour cells, is taken up by CD8+ T cells in the tumour microenvironment and blocks their proliferation and cytotoxicity by inhibition of lactate dehydrogenase and metabolic reprogramming.

    • Joseph Willson
    Research Highlight
  • Social media has revolutionized health-care communication across medicine, particularly in the field of oncology. In this Comment, Manochakian and Dizon highlight the role of social media in promoting patient-driven cancer research to benefit all.

    • Rami Manochakian
    • Don S. Dizon
  • In two studies published concurrently, Dohlman et al. and Narunsky-Haziza et al. have found strong correlative links between the prevalence of fungal DNA and cancer.

    • Gabrielle Brewer
    Research Highlight
A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.


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