Jumping frog

Towards targeting transposable elements for cancer therapy

Yonghao Liang, Xuan Qu, Nakul M. Shah and Ting Wang

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  • In this Tools of the Trade, Juliann Shih describes the development of BISCUT, which detects genomic loci that are subject to fitness advantages or disadvantages by interrogating the length distributions of partial somatic copy-number alterations to enable the discovery of new drivers of aneuploidy in cancer.

    • Juliann Shih
    Tools of the Trade
  • Mutant gain-of-function p53 is commonly found in human cancers. Huang, Cao, Qian et al. developed and validated the use of multifunctional biomimetic nanoreceptors that bind to and promote the degradation of mutant p53 as a cancer therapy.

    • Gabrielle Brewer
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  • In this Tools of the Trade article, Vakul Mohanty describes the development and use of METAFlux, a computational framework that infers metabolic flux from bulk and single-cell RNA-sequencing data.

    • Vakul Mohanty
    Tools of the Trade
  • Goddard et al. report that disseminated tumour cells evade T cell immunity due to their relative scarcity, which decreases the likelihood of T cell–tumour cell interactions.

    • Daniela Senft
    Research Highlight
  • Zhao et al. identified lymphatic endothelial-like cells in glioblastoma and demonstrated their role in promoting tumour growth through increased glioblastoma cholesterol metabolism.

    • Gabrielle Brewer
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  • In this Journal Club, Taboada and Riechelmann discuss the importance of a study outlining a novel neuroendocrine neoplasm classification system.

    • Rodrigo Gomes Taboada
    • Rachel P. Riechelmann
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Six human body silhouettes, the three on the left are male-shaped, the three on the right female.

Sex differences in cancer

Sex differences begin at fertilization and affect nearly all body systems during development.
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