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Cancer therapy with antibodies

Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Katharine M. Wright, Sandra B. Gabelli, Mitchell Ho, Andrea van Elsas & Shibin Zhou

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    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

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    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

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    • Metastasis to the leptomeninges causes substantial neurological morbidity and mortality. Owing to the lack of mechanistic studies in this area, patients still face a bleak clinical prognosis. In this Review, Remsik and Boire provide a biology-focused overview of recent developments enabled by preclinical models and omics analyses and outline the need for further mechanistic research on leptomeningeal metastasis.

      • Jan Remsik
      • Adrienne Boire
      Review Article
    • In this Perspective, Holder et al. discuss the limitations of current predictive biomarkers of response to immune checkpoint inhibitors and the need to further explore static, dynamic and patient-specific biomarkers using novel tools, such as machine learning and consortia-level initiatives.

      • Ashley M. Holder
      • Aikaterini Dedeilia
      • Genevieve M. Boland
      Perspective
    • This Review provides an introductory guide to artificial intelligence (AI)-based tools for non-computational cancer researchers. Here, Perez-Lopez et al. outline the general principles of AI for image analysis, natural language processing and drug discovery, as well as how researchers can get started with each of them.

      • Raquel Perez-Lopez
      • Narmin Ghaffari Laleh
      • Jakob Nikolas Kather
      Review Article
    • In this Review, Paul et al. provide an overview of therapeutic antibodies as an important modality in cancer therapy today. They summarize the different approaches used by antibodies to target cancer cells including those of immune checkpoint inhibitors, bispecific antibodies and antibody–drug conjugates, as well as describing current strategies aimed at improving their efficacy and reducing toxicities.

      • Suman Paul
      • Maximilian F. Konig
      • Shibin Zhou
      Review Article
    • In this Review, Zhang and colleagues provide an overview of the molecular characteristics of paediatric cancer and highlight how these malignancies arise from developmental aberrations resulting in paediatric-specific cancer genomes that influence both the initiation and progression of cancer. Additionally, they discuss genetic vulnerabilities within these cancer genomes that present opportunities for therapeutic interventions.

      • Xiaolong Chen
      • Wentao Yang
      • Jinghui Zhang
      Review Article
  • In this Tools of the Trade article, Erin Brown describes the development of CytoSPACE, a computational tool that aligns single-cell transcriptomes and spatial transcriptomic data, and highlights its use in identifying spatially resolved cell states in the tumour microenvironment.

    • Erin L. Brown
    Tools of the Trade
  • To establish microbiome-based screening for colorectal cancer, a study published in Nature Medicine tackled two key challenges: utilizing quantitative microbiome profiling and identifying covariates that might obscure the microbiota–colorectal cancer interactions.

    • Daniela Senft
    Research Highlight
  • Monteran et al. identified key interactions between granulocytes and T cells that promote an immunosuppressive bone microenvironment, enabling breast cancer metastasis.

    • Gabrielle Brewer
    Research Highlight
  • Parreno et al. provide evidence for epigenetically initiated cancers in Drosophila and show that cancer develops after transient loss of Polycomb group proteins in the absence of recurrent mutations.

    • Daniela Senft
    Research Highlight
  • In this Journal Club, Lim and Jeon discuss a recent study demonstrating the utility of noninvasive genomic profiling for subtyping Hodgkin lymphomas.

    • Sojung Lim
    • Yoon Kyung Jeon
    Journal Club
  • Kong et al. have now shown that Knudson’s two-hit hypothesis can be circumvented through the actions of the glycolytic metabolite methylglyoxal, which transiently inactivates the tumour-suppressive functions of BRCA2 leading to episodic mutagenesis and cancer genome evolution.

    • Anna Dart
    Research Highlight
Six human body silhouettes, the three on the left are male-shaped, the three on the right female.

Sex differences in cancer

Sex differences begin at fertilization and affect nearly all body systems during development.
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