Exploiting senescence for the treatment of cancer

Liqin Wang, Lina Lankhorst & Rene Bernards


  • birthday balloons that look like cancer cells making the number 20

    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

  • two people representing an early-career researcher and their mentor

    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • "crab" symbol formed from individual cancer cells

    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

  • group of women

    This series of articles explores recent advances in our understanding of tumour metabolism and growth in the context of systemic regulation, diet and metabolic disease.


  • In this Journal Club, Kanaan and Copeland discuss a study showing that a high 1,25(OH)2D:25(OH)D molar ratio, indicative of vitamin D metabolism, is inversely related to the risk of highly aggressive prostate cancer in African American men.

    • Yasmine Kanaan
    • Robert L. Copeland
    Journal Club
  • Chen et al. show that gliomagenesis in the olfactory bulb of the brain is directly related to olfactory perception in mice.

    • Anna Dart
    Research Highlight
  • Reticker-Flynn et al. show that exposure of melanoma cells to interferons and immune cells within lymph nodes leads to immune tolerance that promotes metastasis of both these cells and primary tumour cells.

    • Caroline Barranco
    Research Highlight
  • In this Tools of the Trade article, Amir Giladi describes the development and use of PIC-seq, which enables the direct enrichment and analysis of conjugates of physically interacting cells in the tumour microenvironment.

    • Amir Giladi
    Tools of the Trade
  • In this Tools of the Trade article, Yaara Oren describes the development and use of the Watermelon system to simultaneously track the lineage, transcriptional profile and proliferative state of each cancer cell in a population, which enables the characterization of rare cycling persister cells.

    • Yaara Oren
    Tools of the Trade
  • This month, Nature Reviews Cancer launches Tools of the Trade articles, in which early career researchers can discuss the methods or techniques that they use to conduct their research.

A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.


Nature Careers