
Exploiting senescence for the treatment of cancer
Liqin Wang, Lina Lankhorst & Rene Bernards
Liqin Wang, Lina Lankhorst & Rene Bernards
This Review discusses molecular circuitry underlying adaptive plasticity in brain cancer stem cells, highlighting the transcriptional classification of the stem cell state, neoplastic evolution and development of therapeutic resilience, and critical brain-specific microenvironmental inputs with the goal of informing next-generation stem-targeted treatment paradigms.