Disconnecting multicellular networks in brain tumours

Varun Venkataramani, Matthias Schneider, Frank Anton Giordano, Thomas Kuner, Wolfgang Wick, Ulrich Herrlinger & Frank Winkler  


  • birthday balloons that look like cancer cells making the number 20

    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

  • two people representing an early-career researcher and their mentor

    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • "crab" symbol formed from individual cancer cells

    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

  • group of women

    This series of articles explores recent advances in our understanding of tumour metabolism and growth in the context of systemic regulation, diet and metabolic disease.


    • In this Viewpoint article, we asked four scientists working in the field of cancer nanomedicine to provide their opinions on how we can truly fulfil the great promise of nanotechnologies for the detection, diagnosis and treatment of patients with cancer.

      • Sangeeta N. Bhatia
      • Xiaoyuan Chen
      • Twan Lammers
    • This review gives an overview of natural killer (NK) cell-based immunotherapies. The authors describe the various engineering strategies used to increase NK cell cytotoxicity and persistence, as well as the current challenges and opportunities for the future design of next-generation NK cell therapies.

      • Tamara J. Laskowski
      • Alexander Biederstädt
      • Katayoun Rezvani
      Review Article
    • Environmental exposure to aristolochic acid-containing plant material and its use in traditional medicines have been linked to a wide range of cancers. In this Review, Das et al. describe the evidence for aristolochic acid as a potent carcinogen and explore the impact of public health measures on preventing aristolochic acid-linked cancers and nephropathy, with a call to action for the implementation of further preventative measures.

      • Samrat Das
      • Shefali Thakur
      • Jiri Zavadil
      Review Article
    • Structural variations (SVs), which comprise genome-level aneuploidies and rearrangements, result in both copy number changes and novel interactions between formerly distant genomic elements. This Perspective discusses how the folding of the 3D genome, and differences in its folding across cell types, affect the formation of SVs and their impact on cancer cell fitness in different cancer types.

      • Frank Dubois
      • Nikos Sidiropoulos
      • Rameen Beroukhim
  • Using single-cell transcriptomic data, Joanito et al. reveal that colorectal cancers can be defined by the presence of one of two major intrinsic epithelial subtypes, and present a refined molecular classification system for these cancers.

    • Joseph Willson
    Research Highlight
  • Finding sex differences in the response of patients with melanoma to BRAF/MEK-targeted therapy, Vellano et al. show that this effect is mediated by androgen receptor expression and demonstrate that androgen receptor blockers can enhance treatment response.

    • Joseph Willson
    Research Highlight
  • Diamantopoulou et al. have found that in both mouse models and patients with breast cancer, the timing of spontaneous circulating tumour cell production coincides with sleep.

    • Anna Dart
    Research Highlight
  • Zhang et al. demonstrate that the adenosine deaminase ADAR1 prevents responsiveness to immune checkpoint blockade (ICB) through acting on cellular Z-nucleic acids, and show inducing Z-nucleic acid formation can induce tumour sensitivity to ICB.

    • Joseph Willson
    Research Highlight
  • In this Journal Club, Kanaan and Copeland discuss a study showing that a high 1,25(OH)2D:25(OH)D molar ratio, indicative of vitamin D metabolism, is inversely related to the risk of highly aggressive prostate cancer in African American men.

    • Yasmine Kanaan
    • Robert L. Copeland
    Journal Club
A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.


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