Patterns

Disconnecting multicellular networks in brain tumours

Varun Venkataramani, Matthias Schneider, Frank Anton Giordano, Thomas Kuner, Wolfgang Wick, Ulrich Herrlinger & Frank Winkler  

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  • birthday balloons that look like cancer cells making the number 20

    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

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    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

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    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

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    This series of articles explores recent advances in our understanding of tumour metabolism and growth in the context of systemic regulation, diet and metabolic disease.

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  • Using single-cell transcriptomic data, Joanito et al. reveal that colorectal cancers can be defined by the presence of one of two major intrinsic epithelial subtypes, and present a refined molecular classification system for these cancers.

    • Joseph Willson
    Research Highlight
  • Finding sex differences in the response of patients with melanoma to BRAF/MEK-targeted therapy, Vellano et al. show that this effect is mediated by androgen receptor expression and demonstrate that androgen receptor blockers can enhance treatment response.

    • Joseph Willson
    Research Highlight
  • Diamantopoulou et al. have found that in both mouse models and patients with breast cancer, the timing of spontaneous circulating tumour cell production coincides with sleep.

    • Anna Dart
    Research Highlight
  • Zhang et al. demonstrate that the adenosine deaminase ADAR1 prevents responsiveness to immune checkpoint blockade (ICB) through acting on cellular Z-nucleic acids, and show inducing Z-nucleic acid formation can induce tumour sensitivity to ICB.

    • Joseph Willson
    Research Highlight
  • In this Journal Club, Kanaan and Copeland discuss a study showing that a high 1,25(OH)2D:25(OH)D molar ratio, indicative of vitamin D metabolism, is inversely related to the risk of highly aggressive prostate cancer in African American men.

    • Yasmine Kanaan
    • Robert L. Copeland
    Journal Club
  • Chen et al. show that gliomagenesis in the olfactory bulb of the brain is directly related to olfactory perception in mice.

    • Anna Dart
    Research Highlight
A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.
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