The Greek god Hermes

The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment

Margarita Bartish, Madelyn J. Abraham, Christophe Goncalves, Ola Larsson, Charlotte Rolny & Sonia V. del Rincon  


  • birthday balloons that look like cancer cells making the number 20

    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

  • two people representing an early-career researcher and their mentor

    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • "crab" symbol formed from individual cancer cells

    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

  • Trees made out of cells

    THE TUMOUR LANDSCAPE: TRANSLATING MECHANISM TO THERAPY. Join Nature Reviews Cancer, alongside Nature and Nature Cancer in New York for our 3rd Nature Conference with MSKCC. This meeting will focus on how to translate recent technological, biological, translational and clinical advances of the tumour ecosystem to the clinic. October 29th, 2023 – November 1st, 2023. Register now!


  • In this study, Insco et al. find patient-specific CDK13 mutations to impede RNA surveillance, leading to the accumulation and translation of prematurely terminated RNAs that drive malignancy in melanoma models.

    • Gabrielle Brewer
    Research Highlight
  • Sloan and colleagues demonstrate that anthracycline chemotherapy drives metastatic progression by stimulating a cancer cell-mediated increase in nerve fibre activity in the tumour microenvironment, which can be reversed by the use of β-blockers.

    • Daniela Senft
    Research Highlight
  • In a recent study on castration-resistant prostate cancer, Cui et al. uncover a role for cancer-associated fibroblasts (CAFs) in inducing androgen synthesis in prostate cancer cells.

    • Gabrielle Brewer
    Research Highlight
  • In this Tools of the Trade article, Zhenqin Wu describes the development and use of SPACE-GM, a graph deep learning tool that enables the detection of spatial cellular structures predictive of outcomes of patients with cancer.

    • Zhenqin Wu
    Tools of the Trade
A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.


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