Aristolochic acid-associated cancers: a public health risk in need of global action

Samrat Das, Shefali Thakur, Michael Korenjak, Viktoriya S. Sidorenko, Felicia Fei-Lei Chung & Jiri Zavadil      


  • birthday balloons that look like cancer cells making the number 20

    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

  • two people representing an early-career researcher and their mentor

    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • "crab" symbol formed from individual cancer cells

    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

  • group of women

    This series of articles explores recent advances in our understanding of tumour metabolism and growth in the context of systemic regulation, diet and metabolic disease.


  • In this Tools of the Trade article, Luigi Ombrato describes the development of Cherry-niche, a cell labelling system, which enables the unbiased identification of cancer cell-neighbouring cells.

    • Luigi Ombrato
    Tools of the Trade
  • Ma et al. demonstrate that platelets suppress liver tumour growth in the context of non-alcoholic fatty liver disease through T cell-dependent antitumour immunity.

    • Daniela Senft
    Research Highlight
  • Xu, Yan et al. show that the hypothalamic–pituitary unit produces α-melanocyte-stimulating hormone in tumour-bearing mice, to promote myelopoiesis and immunosuppression.

    • Gabrielle Brewer
    Research Highlight
  • In this Tools of the Trade article, Daniela S. Thommen describes the development and use of a patient-derived tumour fragment (PDTF) platform wherein surgically resected tumour lesions are cultured ex vivo, which enables patients’ responses to immunotherapy to be more faithfully modelled.

    • Daniela S. Thommen
    Tools of the Trade
  • In two studies published concurrently, Pal et al. and Shi et al. reveal that certain gliomas rely on the de novo synthesis of pyrimidines. These studies go on to demonstrate the effectiveness of brain-penetrant inhibitors of de novo pyrimidine synthesis in preclinical models of glioma.

    • Joseph Willson
    Research Highlight
A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.


Nature Careers